Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143249..143754 Replicon chromosome
Accession NZ_CP054790
Organism Pseudomonas aeruginosa strain SE5418

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HUK71_RS00660 Protein ID WP_003083773.1
Coordinates 143249..143530 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HUK71_RS00665 Protein ID WP_003083775.1
Coordinates 143527..143754 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUK71_RS00635 (HUK71_00635) 138500..139849 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
HUK71_RS00640 (HUK71_00640) 139898..140584 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
HUK71_RS00645 (HUK71_00645) 140685..141419 + 735 WP_003117208.1 GntR family transcriptional regulator -
HUK71_RS00650 (HUK71_00650) 141599..142009 + 411 WP_003101225.1 aegerolysin family protein -
HUK71_RS00655 (HUK71_00655) 142041..142949 - 909 WP_010793581.1 LysR family transcriptional regulator -
HUK71_RS00660 (HUK71_00660) 143249..143530 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HUK71_RS00665 (HUK71_00665) 143527..143754 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HUK71_RS00670 (HUK71_00670) 143930..144550 - 621 WP_003101226.1 hypothetical protein -
HUK71_RS00675 (HUK71_00675) 144651..145151 + 501 WP_003101228.1 LEA type 2 family protein -
HUK71_RS00680 (HUK71_00680) 145224..145565 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
HUK71_RS00685 (HUK71_00685) 145647..147074 - 1428 WP_003083784.1 GABA permease -
HUK71_RS00690 (HUK71_00690) 147243..148736 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T160452 WP_003083773.1 NZ_CP054790:c143530-143249 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T160452 NZ_CP070507:14319-14600 [Pseudomonas sp. SDM007]
ATGCGGACGATTGAACAGACCAGCCGGTTCAAACGCGATTATAAACGCGAAGCCAAAGGCCCGCATCGTCAGACGCTGGC
GAGCGATTTCATTGCCGTCGTCACAGCCCTGGCGAATAACCAGCCTCTGGCCGAGAAGCACCGTGACCACGCCCTCACCG
GCGACTGGAAAGACCACCGGGACTGTCACATCAAGCCCGACCTGGTGTTGATTTACCGCAAGCCGGATGACGCCGTGCTG
CAACTCGTGCGTCTCGGATCGCATAGCGAGCTTGGCCTGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT160452 WP_003083775.1 NZ_CP054790:c143754-143527 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT160452 NZ_CP070507:14069-14332 [Pseudomonas sp. SDM007]
ATGTCCGCAAATGCTGTAGTCCGTGCCCGTATCGACGAGCACATCAAGGAAGAGGCGACCGTCGTGCTGGCAGCGATGGG
ACTCACCGTGTCTGACGCCTTCCGCATCATGTTGACCCGAGTCGCCCGCGAGAAAGCCTTGCCGTTCGAGCCGCTGATTC
CGAACGCCACCACCATCGAGGCGATGAAGGAAGCGCGCCGTGGCGGCTTGAAGTCGTTCGCTTCCGTCGAGGATCTGATG
GCGGATCTGAATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References