Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1963040..1964548 Replicon chromosome
Accession NZ_CP054789
Organism Pseudomonas aeruginosa strain SE5381

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag HUK70_RS09500 Protein ID WP_003119682.1
Coordinates 1963040..1963627 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A1C7C4U7
Locus tag HUK70_RS09505 Protein ID WP_003091607.1
Coordinates 1963694..1964548 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUK70_RS09495 (HUK70_09450) 1959295..1962774 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
HUK70_RS09500 (HUK70_09455) 1963040..1963627 + 588 WP_003119682.1 GNAT family protein Toxin
HUK70_RS09505 (HUK70_09460) 1963694..1964548 + 855 WP_003091607.1 AraC family transcriptional regulator Antitoxin
HUK70_RS09510 (HUK70_09465) 1964645..1966810 + 2166 WP_010793245.1 TonB-dependent receptor family protein -
HUK70_RS09515 (HUK70_09470) 1966985..1968859 + 1875 WP_010793244.1 MFS transporter -
HUK70_RS09520 (HUK70_09475) 1968920..1969129 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T160447 WP_003119682.1 NZ_CP054789:1963040-1963627 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T160447 NZ_CP070506:1770860-1771048 [Pseudomonas sp. SDM007]
GTGCAAAGCAGGCTATTGATCAAGGAACTGCAAGCGGCGGGCTGGGTGCTGGATCGGGTCACGGGCAGCCATCATATTTT
CACTCATCGCTATAACCCGTACACGATACCGGTGCCCCATCCCAAGAAGGACCTGCCCTTGGGCACCGTACGAAGTATCA
GGCAGCGCGCCGGGCTGTTTTCGTTCTAG

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31895.20 Da        Isoelectric Point: 7.5295

>AT160447 WP_003091607.1 NZ_CP054789:1963694-1964548 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT160447 NZ_CP070506:1771072-1771476 [Pseudomonas sp. SDM007]
ATGCAATACCCAATCTGTATCGAATGGGGCGATGACTTTACCGCCACCGGTATCCAGATCCCCGACATTCCTGGTGCAGT
GACCGCCGGGGACAGTTTTGAAGAGGCGTACAACGCAGCGGTCGAAGTGGCGCACATCATGCTGCAGGAGATGGCGAGTG
AAGGCCGGGCGATTCCCATGCCGACCTCAGTCGCGGCGTACCACGGCAACGACGAATACGCGGGCATGGGCTGGGGCATG
CTGGAGCTCGATATCTCGCCTTATCTGGGCAAGACCGAGAAGGTCAATGTGACATTGCCAGGCTATGTGATCCAGCGCAT
TGACCGGTATGTGCGCGAACACAAGGTGAAGAGCCGCTCGTCATTCCTGGCGGATGCGGCGCTGGAGAAGTTGGTGCGTT
CTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C4U7

References