Detailed information of TA system TA160440

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4645745..4647003
• Replicon: chromosome
• Accession: NZ_CP054788
• Organism: Pseudomonas aeruginosa strain YTSY4

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HUK69_RS21920
• Protein ID: WP_003163133.1
• Coordinates: 4645745..4646500 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: HUK69_RS21925
• Protein ID: WP_003086329.1
• Coordinates: 4646635..4647003 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUK69_RS21910 (HUK69_21880)	4640917..4643460	+	2544	WP_033876574.1	acyl-homoserine-lactone acylase QuiP	-
HUK69_RS21915 (HUK69_21885)	4643615..4644976	-	1362	WP_003120632.1	DNA recombination protein RmuC	-
HUK69_RS21920 (HUK69_21890)	4645745..4646500	-	756	WP_003163133.1	RES family NAD+ phosphorylase	Toxin
HUK69_RS21925 (HUK69_21895)	4646635..4647003	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
HUK69_RS21930 (HUK69_21900)	4647076..4648362	-	1287	WP_003163134.1	FAD-binding oxidoreductase	-
HUK69_RS21935 (HUK69_21905)	4648418..4650007	-	1590	WP_209358605.1	aldehyde dehydrogenase family protein	-
HUK69_RS21940 (HUK69_21910)	4650086..4650562	+	477	WP_003112531.1	hypothetical protein	-
HUK69_RS21945 (HUK69_21915)	4650565..4650840	-	276	WP_169057979.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28250.37 Da
• Isoelectric Point: 7.7294

>T160440 WP_003163133.1 NZ_CP054788:c4646500-4645745 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T160440 NZ_CP070503:3771967-3772236 [Pseudomonas atacamensis]
ATGCAGATTGAGTGGCGGCCCGAAGCCAAGGCCGATCTTTCGAACATCCTCAGATACATTGGCGAGAGAAACTTTGCAGC
CGCAGTGAGTCTCTCGAAATCCATCGAAGAATCCACAACCTCACTCTCCGTTCATCCCCATCTCTACCGTAAAGGTCGAT
CTCCCGGCACCCGGGAAATCGTTGTACATCCTAACTACGTAGTGATTTATGAGGTGACGGATCGAATCGAGATACTCAGC
GTTTTGCATACCCGACAGGAATATCCATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT160440 WP_003086329.1 NZ_CP054788:c4647003-4646635 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT160440 NZ_CP070503:3771786-3771977 [Pseudomonas atacamensis]
ATGGACGGCAAAATCTTTCCCGACGATTCAGGGTTTGAAAACGACGAGCAGGCTGCCAGTCATGATCGCTGGTTGCGAGC
CAAGGTGCAGGCGTCCAGAGATGATCCCCATCCGAGTCTCCCCCATGAGGACGTGATGGCGGACATGCATGCCTTGATCG
AATCCATGCGAAAAAAGGCCGATGCAGATTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7