160439

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3704566..3705787 Replicon chromosome
Accession NZ_CP054788
Organism Pseudomonas aeruginosa strain YTSY4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HUK69_RS17530 Protein ID WP_003160088.1
Coordinates 3705209..3705787 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HUK69_RS17525 Protein ID WP_003117666.1
Coordinates 3704566..3705120 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUK69_RS17500 (HUK69_17480) 3700134..3700685 + 552 WP_016253541.1 helix-turn-helix domain-containing protein -
HUK69_RS17505 (HUK69_17485) 3700682..3701080 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
HUK69_RS17510 (HUK69_17490) 3701093..3701416 - 324 WP_003102734.1 multidrug efflux SMR transporter -
HUK69_RS17515 (HUK69_17495) 3701747..3702208 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
HUK69_RS17520 (HUK69_17500) 3702213..3704408 + 2196 WP_003117665.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
HUK69_RS17525 (HUK69_17505) 3704566..3705120 + 555 WP_003117666.1 helix-turn-helix transcriptional regulator Antitoxin
HUK69_RS17530 (HUK69_17510) 3705209..3705787 + 579 WP_003160088.1 HD domain-containing protein Toxin
HUK69_RS17535 (HUK69_17515) 3705896..3707083 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
HUK69_RS17540 (HUK69_17520) 3707073..3709244 - 2172 WP_108201966.1 type I secretion system permease/ATPase -
HUK69_RS17545 (HUK69_17525) 3709234..3710511 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-66)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T160439 WP_003160088.1 NZ_CP054788:3705209-3705787 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T160439 NZ_CP070503:c3327085-3326804 [Pseudomonas atacamensis]
ATGACCTATGAACTGGAATTTTCTGAAAAGGCTTGGAAGGAGTGGCGAAAGCTTGGGTCGGAGCTCAGAGAGCAGTTCAA
AAATAAACTTGTTGAAAGGCTGGCAAATCCCCACGTTCCGGCGGCTCGTCTGAAAGGATTGTGTAACGCCTATAAAATCA
AGCTTCGAAGCGCTGGATATCGGTTGGTCTATCGGGTCAGGGACGAGGTACTGGTCGTTACGGTGATAGCGGTTGGGAAA
CGGCAGGGTGGTGATGTGTACAGGCAGGCACTCAACCGCTGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.67 Da        Isoelectric Point: 8.5356

>AT160439 WP_003117666.1 NZ_CP054788:3704566-3705120 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADKALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT160439 NZ_CP070503:c3327323-3327075 [Pseudomonas atacamensis]
ATGACGCACATTGTTCTTTCTCACGTCGTAGCGAGTATTTCCGAATTGAAAAAAAATCCTATGGGTACAGTGGCAGCTGG
TGGAGGCCGGTCTGTGGCGATCCTTAATCGAAACGAACCGGCCTTCTACTGTGTTCCTGCCAAGGAATATGAAGCAATGA
TGGAGCGCCTGGAGGATCTGGAACTGATCGCCCTTTGCAAGGAGCGAGAAAACGATCCGACCATCAAGGTATCCATTGAT
GACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References