Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 2011312..2012820 Replicon chromosome
Accession NZ_CP054788
Organism Pseudomonas aeruginosa strain YTSY4

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag HUK69_RS09245 Protein ID WP_003119682.1
Coordinates 2012233..2012820 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A9E8LAI1
Locus tag HUK69_RS09240 Protein ID WP_003117606.1
Coordinates 2011312..2012166 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUK69_RS09225 (HUK69_09220) 2006731..2006940 + 210 WP_003091604.1 cold-shock protein -
HUK69_RS09230 (HUK69_09225) 2007001..2008875 - 1875 WP_016562131.1 MFS transporter -
HUK69_RS09235 (HUK69_09230) 2009050..2011215 - 2166 WP_003115567.1 TonB-dependent receptor family protein -
HUK69_RS09240 (HUK69_09235) 2011312..2012166 - 855 WP_003117606.1 AraC family transcriptional regulator Antitoxin
HUK69_RS09245 (HUK69_09240) 2012233..2012820 - 588 WP_003119682.1 GNAT family protein Toxin
HUK69_RS09250 (HUK69_09245) 2013086..2016565 + 3480 WP_235195781.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T160437 WP_003119682.1 NZ_CP054788:c2012820-2012233 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T160437 NZ_CP070503:c2697866-2697597 [Pseudomonas atacamensis]
CTGCCGGTTAGCTGGAGTAAACCGGCTCTTGGAGATCTGGCTGACATCATCGAATACGTAGAACAACGCAACACTGTCGC
TTCAGTTGCACTGCACCAAAAGCTCAGCGCCGCAGCGCGAAGGCTTTCCTGGATACCGCATGGTTTCCGCTCCGGCCGAA
TACCGGGCACTCGCGAAATGGTCATCAACTCGAATTATTTACTGGTCTATCGGGTGACAGACCACATCAAAATTCTGACC
TTGTTGCACGCCCGTAAAAAATATCCATAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31863.14 Da        Isoelectric Point: 7.5295

>AT160437 WP_003117606.1 NZ_CP054788:c2012166-2011312 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT160437 NZ_CP070503:c2698050-2697856 [Pseudomonas atacamensis]
ATGAGCGCTGAACTTTCACTTATCGTTTCAGACTTCGAAACCGAAGAAGAGGCTGCGGATTACGACCTTTGGTATCGCGC
CAAGGTACAAGCCGCACTTGATGATCCACGCCCGCCTATCCCCCATGATGAGGCAATGGTGCTGCTAGGTCAGATGCTGG
AAGAGAGACGCAAGAATCGACGCGCTGCCGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References