Detailed information of TA system TA160433

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4667918..4669176
• Replicon: chromosome
• Accession: NZ_CP054787
• Organism: Pseudomonas aeruginosa strain HB2011305RE

Toxin (Protein)

• Gene name: -
• Uniprot ID: V6AJ34
• Locus tag: HUK67_RS22075
• Protein ID: WP_003086331.1
• Coordinates: 4667918..4668673 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: HUK67_RS22080
• Protein ID: WP_003086329.1
• Coordinates: 4668808..4669176 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUK67_RS22065 (HUK67_22045)	4663089..4665632	+	2544	WP_033979231.1	acyl-homoserine-lactone acylase QuiP	-
HUK67_RS22070 (HUK67_22050)	4665788..4667149	-	1362	WP_003120632.1	DNA recombination protein RmuC	-
HUK67_RS22075 (HUK67_22055)	4667918..4668673	-	756	WP_003086331.1	RES family NAD+ phosphorylase	Toxin
HUK67_RS22080 (HUK67_22060)	4668808..4669176	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
HUK67_RS22085 (HUK67_22065)	4669249..4670535	-	1287	WP_003086327.1	FAD-binding oxidoreductase	-
HUK67_RS22090 (HUK67_22070)	4670591..4672180	-	1590	WP_023464367.1	aldehyde dehydrogenase family protein	-
HUK67_RS22095 (HUK67_22075)	4672259..4672735	+	477	WP_004353334.1	elongation factor GreAB	-
HUK67_RS22100 (HUK67_22080)	4672738..4673013	-	276	WP_023088486.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28236.34 Da
• Isoelectric Point: 7.7294

>T160433 WP_003086331.1 NZ_CP054787:c4668673-4667918 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T160433 NZ_CP070501:284027-284419 [Agrococcus sp. Marseille-Q4369]
GTGCTCGTCGACACGTCTGCGTGGATCGAGTTCCTGCGCGCGACGGGATCGCGCGCGCACGTCGCGCTCCGGGACGCCCT
CCGCGACGAACGCCGGCTGGTCGTCTGCGAGCCCGTGCAGATGGAGGTGCTCGCCGGCGCCCGCTCCGAGCAGCACGTCG
CCGAGCTGCGCGGGCTCCTCGCCCGATGCGAGCTCGTACGCACCGTCCCGAGCGACTGGGACGACGCGGCTCGCATCTAC
CGGACGGGGCGTCGACAAGGAGTGACGATCCGCAAGCTCGTGGATTGCCTCATCGCCGCGATGGCGATGCGGGCAGGTGA
GCCGCTGCTGTACGCCGGTGCGGACTTCGACGCGATCGCTCGCGTGACCGACCTCGACGCGGTCAGGGGATAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT160433 WP_003086329.1 NZ_CP054787:c4669176-4668808 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT160433 NZ_CP070501:283824-284024 [Agrococcus sp. Marseille-Q4369]
ATGGCGCGCACCAACATCGACCTCGACGAGTCGGCCGTCGAAGCGGTCATGCGCCGCTTCTCGTTCACGACGAAGCGCGA
GGCCGTGAACTACGCGCTCCGCGCTCTGGCGTCAGAGCCGCTCGACGTCGCGGGCGCTCTCGCCTTGGAGGGCTCCGGGT
GGGACGCGGATCTGGACGAGCTCCGCGCATCGAGGGCCTGA

Structures

Toxin

• AlphaFold DB: V6AJ34

Antitoxin

• AlphaFold DB: V6AJU7