Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 160346..160851 Replicon chromosome
Accession NZ_CP054787
Organism Pseudomonas aeruginosa strain HB2011305RE

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HUK67_RS00760 Protein ID WP_003083773.1
Coordinates 160346..160627 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HUK67_RS00765 Protein ID WP_003083775.1
Coordinates 160624..160851 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUK67_RS00735 (HUK67_00735) 155597..156946 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
HUK67_RS00740 (HUK67_00740) 156995..157681 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
HUK67_RS00745 (HUK67_00745) 157782..158516 + 735 WP_004346926.1 GntR family transcriptional regulator -
HUK67_RS00750 (HUK67_00750) 158696..159106 + 411 WP_003101225.1 aegerolysin family protein -
HUK67_RS00755 (HUK67_00755) 159138..160046 - 909 WP_003083769.1 LysR family transcriptional regulator -
HUK67_RS00760 (HUK67_00760) 160346..160627 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HUK67_RS00765 (HUK67_00765) 160624..160851 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HUK67_RS00770 (HUK67_00770) 161027..161647 - 621 WP_003101226.1 hypothetical protein -
HUK67_RS00775 (HUK67_00775) 161748..162248 + 501 WP_003101228.1 LEA type 2 family protein -
HUK67_RS00780 (HUK67_00780) 162321..162662 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
HUK67_RS00785 (HUK67_00785) 162744..164171 - 1428 WP_003083784.1 GABA permease -
HUK67_RS00790 (HUK67_00790) 164340..165833 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T160429 WP_003083773.1 NZ_CP054787:c160627-160346 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T160429 NZ_CP070499:c4523646-4523380 [Natronosporangium hydrolyticum]
GTGACCTACCGGATCGAGCTGACCAGGGCGGCCCGGAGGGCGTTGGTAAAAGATCTGCCCGAGGTCGCCGCGGTGGCCTG
CTGGGAATTCATCCGGGGCCCGCTCAGCGAACATCCGCACCGGGTGGGCAAGGCCCTGCGTGATCAACTGGCGGGCCACT
ACTCGGCCCGTCGTGGCGAGTTTCGAGTCATCTATCAGATCTATGAGGATCGGGTCGTGGTCCGAGTCGTCGCCATCCGC
CATCGCCGTGACGCGTACCAGCGGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT160429 WP_003083775.1 NZ_CP054787:c160851-160624 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT160429 NZ_CP070499:c4523927-4523643 [Natronosporangium hydrolyticum]
ATGACGACAATCCCGCTCGCCGAGGCCAGAGCCAACCTCTCCCGCCTGGTCGACGAGGCTGTGCGCACTCATGAGCGGGT
GGAGGTGACGCGAAAGGGGCGGCGGGCGGCGGTGATCATGAGCGCGGACGACTACGACTCGATCATGGAGACGCTCGACA
TCCTGAGCGATCCGGAGCTGGTCCGCGAGATCCGGGCAGCAACGGCCGAAGCGGAGCAGGGCGAGGTATTCAGCCTCGAA
GAGGTGACTGAGGAGATGCGCGCCCACGGGCGGTTGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References