Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 6391282..6392790 Replicon chromosome
Accession NZ_CP054786
Organism Pseudomonas aeruginosa strain DL201330

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag HUK64_RS29820 Protein ID WP_003119682.1
Coordinates 6391282..6391869 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A9E8LAI1
Locus tag HUK64_RS29825 Protein ID WP_003117606.1
Coordinates 6391936..6392790 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUK64_RS29815 (HUK64_29795) 6387537..6391016 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
HUK64_RS29820 (HUK64_29800) 6391282..6391869 + 588 WP_003119682.1 GNAT family protein Toxin
HUK64_RS29825 (HUK64_29805) 6391936..6392790 + 855 WP_003117606.1 AraC family transcriptional regulator Antitoxin
HUK64_RS29830 (HUK64_29810) 6392887..6395052 + 2166 WP_015649209.1 TonB-dependent receptor family protein -
HUK64_RS29835 (HUK64_29815) 6395227..6397101 + 1875 WP_003117607.1 MFS transporter -
HUK64_RS29840 (HUK64_29820) 6397162..6397371 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T160428 WP_003119682.1 NZ_CP054786:6391282-6391869 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T160428 NZ_CP070499:c4425030-4424683 [Natronosporangium hydrolyticum]
ATGCGTCGCGGTGAGGTCTACCTGGTCGATCTCGAACCAGCGCAGGGTGCCGAAGCAAACAAGGTGCGCCCCGCGGTCGT
GGTCAGCAACGACGCCGCGAATCGAAGCGCGGAGCAGACCGGCCGCGGGGTGGTGACGGTCGTCCCGGTCACCTCCAACA
CCGGCCGGGTCTACCCTTTCCAGGTGCTGCTGCGGGCTGCCGACAGTGGCCTGCGGGAGGATTCGAAGGCGCAAGCAGAG
CAGGTTCGTTCGGTGGCCGTGCGGCGGATCCGGCAGCGGGTCGGCGGGCTGCCGGCGCCAGTGCTGGCGGAGTTGGACCG
GGCGCTGCGGCTCCACCTCGCGTTGTAG

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31863.14 Da        Isoelectric Point: 7.5295

>AT160428 WP_003117606.1 NZ_CP054786:6391936-6392790 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT160428 NZ_CP070499:c4425253-4425017 [Natronosporangium hydrolyticum]
ATGAAGCTGAGTGTCAGCCTACCCGAGGCCGACGTGGCCTTCCTGGACGACTACGCGACCCGGGCCGGAGGGTCGTCTCG
GTCCTCGGTCGTCCAGCGGGCGATTCGGCTACTCCGGACCGCCGAGCTGGAGGAGGCGTACGCGCACGCTTACCAGGAGT
GGGAGGCGAGCGAGGACGCCGAACTCTGGGATCGGGCGGCCGGCGACGGTGATGGTTACGGCGATGCGTCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References