Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5995855..5996511 Replicon chromosome
Accession NZ_CP054786
Organism Pseudomonas aeruginosa strain DL201330

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HUK64_RS27940 Protein ID WP_033971890.1
Coordinates 5996329..5996511 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HUK64_RS27935 Protein ID WP_023875730.1
Coordinates 5995855..5996283 (-) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUK64_RS27895 (HUK64_27875) 5991898..5992611 + 714 WP_003159463.1 phage antirepressor KilAC domain-containing protein -
HUK64_RS27900 (HUK64_27880) 5992676..5993437 + 762 WP_198580818.1 helix-turn-helix domain-containing protein -
HUK64_RS27905 (HUK64_27885) 5993434..5994117 + 684 WP_198580819.1 replication protein P -
HUK64_RS27910 (HUK64_27890) 5994114..5994320 + 207 WP_198580820.1 hypothetical protein -
HUK64_RS27915 (HUK64_27895) 5994317..5994688 + 372 WP_121147581.1 Ref family recombination enhancement nuclease -
HUK64_RS27920 (HUK64_27900) 5994685..5995032 + 348 WP_058161108.1 RusA family crossover junction endodeoxyribonuclease -
HUK64_RS27925 (HUK64_27905) 5995029..5995328 + 300 WP_073652357.1 hypothetical protein -
HUK64_RS27930 (HUK64_27910) 5995330..5995704 + 375 WP_016852550.1 antiterminator Q family protein -
HUK64_RS27935 (HUK64_27915) 5995855..5996283 - 429 WP_023875730.1 transcriptional regulator Antitoxin
HUK64_RS27940 (HUK64_27920) 5996329..5996511 - 183 WP_033971890.1 type II toxin-antitoxin system HicA family toxin Toxin
HUK64_RS27945 (HUK64_27925) 5996711..5997043 + 333 WP_043494869.1 phage holin, lambda family -
HUK64_RS27950 (HUK64_27930) 5997040..5997657 + 618 WP_128542531.1 glycoside hydrolase family 19 protein -
HUK64_RS27955 (HUK64_27935) 5997657..5997896 + 240 WP_023114598.1 hypothetical protein -
HUK64_RS27960 (HUK64_27940) 5997893..5998363 + 471 WP_124173773.1 lysis system i-spanin subunit Rz -
HUK64_RS27965 (HUK64_27945) 5998360..5999103 + 744 WP_128542530.1 hypothetical protein -
HUK64_RS27970 (HUK64_27950) 5999235..5999762 + 528 WP_058143933.1 terminase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5965366..6027009 61643


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-78)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6776.89 Da        Isoelectric Point: 11.0775

>T160427 WP_033971890.1 NZ_CP054786:c5996511-5996329 [Pseudomonas aeruginosa]
MKFSEFRRWLKAQGVTFEAGKGSHFKITAPNGKQTTFADHGTKEMPEPTRKAIIKQLGLK

Download         Length: 183 bp

>T160427 NZ_CP070499:3224208-3224591 [Natronosporangium hydrolyticum]
GTGATCCTGATCGACAGCGATGTGCTCATCGCCCACCTTCGAGGAGTCGAGCCGGCACGTGACTGGCTCCGGAAGGCCCG
GACCACCGGACCGCTCGCGGTTAGTGTCGTCTCGATCGCCGAACTCACTGGCGGTATGCGGTCGGCCGAACGGCGGGAGG
TGTTTGCCTTGCTCGGAGCACTTCGCGCGGAGCCGGTCACCGAGTTGGTTGCCCGGCGTGCGGGCGAGTTCATGCGCCAG
TATCGTCGCAGCCACAACGGTATCGGCATCGCCGACTACCTGATCGCCGCCACTGCGGAGCTGCATGGACAACAGCTCGC
CACCCTGAACGTGCGGCACTTCCCGATGTTCGCCGACCTGCGGCCACCGTTCGAAGTTCCGTAA

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15758.92 Da        Isoelectric Point: 4.6562

>AT160427 WP_023875730.1 NZ_CP054786:c5996283-5995855 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSYGDDKAHAISEAVDAIESTLSLYVDQRREIPAASQAQPGERVIHLPAVTVA
KIALWNEMVRRDMRKADLCRLLGIAQTQGDRLVDFLHNTKMEAMENALSALGLRLSVNIEAA

Download         Length: 429 bp

>AT160427 NZ_CP070499:3223954-3224211 [Natronosporangium hydrolyticum]
ATGACGCGCACCAACATCTACCTCGAGGAGCGGCAGACCGCGATTCTTGACCGGATCGCTGGCGAGGAAGGTGTGTCCCG
TGCCGAGGTCATCCGCCGGCTGATCGATCGAGCGCTGGCCGGCCGCGACGATGATCTCACCGCGGACTTGGCTGCCATCG
ACGAGTCATTCGGCGCCCTCGGCGAGCTGGATGTGCCGGCCCGCGGCGCCAGCGATCGGGAGGCGCACCTGTCGCGCATG
TGGCAGGTAGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References