Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4170211..4170830 Replicon chromosome
Accession NZ_CP054774
Organism Klebsiella pneumoniae strain KP20194a2

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HUR99_RS20720 Protein ID WP_002892050.1
Coordinates 4170612..4170830 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HUR99_RS20715 Protein ID WP_002892066.1
Coordinates 4170211..4170585 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUR99_RS20705 4165363..4166556 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HUR99_RS20710 4166579..4169725 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
HUR99_RS20715 4170211..4170585 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HUR99_RS20720 4170612..4170830 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HUR99_RS20725 4170989..4171555 + 567 WP_002892030.1 maltose O-acetyltransferase -
HUR99_RS20730 4171527..4171667 - 141 WP_004147370.1 hypothetical protein -
HUR99_RS20735 4171688..4172158 + 471 WP_002892026.1 YlaC family protein -
HUR99_RS20740 4172133..4173584 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HUR99_RS20745 4173685..4174383 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HUR99_RS20750 4174380..4174520 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HUR99_RS20755 4174520..4174783 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T160379 WP_002892050.1 NZ_CP054774:4170612-4170830 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T160379 NZ_CP070482:2238734-2238952 [Escherichia coli]
ATGTCCGAAAAATTTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT160379 WP_002892066.1 NZ_CP054774:4170211-4170585 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT160379 NZ_CP070482:2238334-2238708 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References