160365

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 2247..2721 Replicon plasmid pKP20194b-p5
Accession NZ_CP054773
Organism Klebsiella pneumoniae strain KP20194b

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag HUS00_RS29330 Protein ID WP_004197762.1
Coordinates 2247..2513 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag HUS00_RS29335 Protein ID WP_000879771.1
Coordinates 2497..2721 (-) Length 75 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS00_RS29315 811..1190 + 380 Protein_0 hypothetical protein -
HUS00_RS29320 1216..1761 + 546 WP_023317533.1 hypothetical protein -
HUS00_RS29325 1827..2177 + 351 WP_004197756.1 hypothetical protein -
HUS00_RS29330 2247..2513 - 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUS00_RS29335 2497..2721 - 225 WP_000879771.1 TraY domain-containing protein Antitoxin
HUS00_RS29340 3388..3600 - 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
HUS00_RS29345 3607..4116 - 510 WP_032433972.1 MbeB family mobilization protein -
HUS00_RS29350 4091..4855 - 765 Protein_7 relaxase/mobilization nuclease domain-containing protein -
HUS00_RS29355 4794..5138 - 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
HUS00_RS29360 5128..5304 - 177 WP_004197757.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-87)

Antitoxin

(4-45)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T160365 WP_004197762.1 NZ_CP054773:c2513-2247 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

>T160365 NZ_CP070480:753718-753972 [Rothia sp. ZJ932]
ATGAAAACAATGACCTACTCAGAATCACGAGCACGTTATGCAGAAGTCATGACGAGCGTAGTCGATGACTGCGAAGAAAT
CGTTATCACCCGCGCTGGGCATGAACCGGTGGTCATGCTTTCTCTACGCGAATATGATTCGCTGAAAGAAACAGCCTACC
TCAAACGCTCACCCCGTAATGCTGCGCGAGTATCTGCATCTATCGAGCGTTTACGCTCAGGCATGGGTAGTGAACACAAC
CTCATCGACGAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT160365 WP_000879771.1 NZ_CP054773:c2721-2497 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp

>AT160365 NZ_CP070480:753977-754231 [Rothia sp. ZJ932]
ATGAAAATTGTCTGGGATGAAGCAGCTTGGGAGGACTACCTGTGGTGGCAGGTACAGGATCGCAAAGTGCTGAAACGAAT
AAACCTGCTCATCAAAAATATTGCCCGCAATGGGCATGAAGGTATCGGAAAACCTGAAGCGCTCAAACATGACTGGTCGG
GCTTTTGGTCCCGGCGTATTACTGATGAGCACAGACTTATCTACGCACTCACAGAGGATAGTCTGCTCATCGCCTCCTGC
CGGTACCACTATTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References