Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4890077..4890593 Replicon chromosome
Accession NZ_CP054756
Organism Klebsiella pneumoniae strain KP20194c

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag HUS02_RS24170 Protein ID WP_002886902.1
Coordinates 4890077..4890361 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HUS02_RS24175 Protein ID WP_002886901.1
Coordinates 4890351..4890593 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS02_RS24145 4885561..4885869 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
HUS02_RS24150 4885954..4886127 + 174 WP_002886906.1 hypothetical protein -
HUS02_RS24155 4886130..4886873 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HUS02_RS24160 4887230..4889368 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
HUS02_RS24165 4889609..4890073 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HUS02_RS24170 4890077..4890361 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUS02_RS24175 4890351..4890593 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUS02_RS24180 4890671..4892581 - 1911 WP_004152270.1 BglG family transcription antiterminator -
HUS02_RS24185 4892604..4893758 - 1155 WP_002886900.1 lactonase family protein -
HUS02_RS24190 4893824..4894564 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T160294 WP_002886902.1 NZ_CP054756:c4890361-4890077 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T160294 NZ_CP070436:38567-38983 [Klebsiella pneumoniae]
ATGACCAAAACCTACATGCTGGATACTAATATCTGCTCTTATATCATGCGCGAACAACCGGAAGCGGTGCTGAAACGCCT
AGAGCAAGCGGTGTTGCGCCGTCACCGGATAGTGGTGTCAGCCATCACCTATGCCGAAATGCGTTTTGGTGCCATCGGTA
AAAGGGCTTCGCCCCGTCATGTGCAGCTGGTGGACGCATTCTGTGCGCGCCTTGATGCCATACTGGCTTGGGATCGGGCC
GCAGTTGACGCTACAACAGAGGTTAAGGCCACGCTAGCAGCTGCCGGCACGCCAATCGGCCCAAACGACACAGCCATTGC
TGGACATGCCATTGCCGCTGGCGCCATCCTGGTGACGAATAATACGCGTGAATTTGAGCGAGTCGCTGGTCTGACGTTTG
AAGACTGGGTGCAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT160294 WP_002886901.1 NZ_CP054756:c4890593-4890351 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT160294 NZ_CP070436:38340-38570 [Klebsiella pneumoniae]
ATGCGAACTGTATCTGTATTCAGGAACGGTAATAACCGGGCCATCCGTCTGCCCCGCGATCTGGACTTTGACGGCGTGAA
CGAACTGGAAATCATCCGCGAGGGCGATACCCTCATCCTGCGGCCGGTAAAACCCAGTTGGAGTTCGTTCCGCCAGGAGG
AAAAAGCTGACGCAGATTTTATGGCGGAGCGTGAAAATGTTGTTAGTGACGAGGGACGTTTTGAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References