Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4891277..4891793 Replicon chromosome
Accession NZ_CP054750
Organism Klebsiella pneumoniae strain KP20194c3

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag HUS03_RS24175 Protein ID WP_002886902.1
Coordinates 4891277..4891561 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HUS03_RS24180 Protein ID WP_002886901.1
Coordinates 4891551..4891793 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS03_RS24150 4886761..4887069 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
HUS03_RS24155 4887154..4887327 + 174 WP_002886906.1 hypothetical protein -
HUS03_RS24160 4887330..4888073 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HUS03_RS24165 4888430..4890568 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
HUS03_RS24170 4890809..4891273 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HUS03_RS24175 4891277..4891561 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUS03_RS24180 4891551..4891793 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUS03_RS24185 4891871..4893781 - 1911 WP_004152270.1 BglG family transcription antiterminator -
HUS03_RS24190 4893804..4894958 - 1155 WP_002886900.1 lactonase family protein -
HUS03_RS24195 4895024..4895764 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T160265 WP_002886902.1 NZ_CP054750:c4891561-4891277 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T160265 NZ_CP070425:335828-336196 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT160265 WP_002886901.1 NZ_CP054750:c4891793-4891551 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT160265 NZ_CP070425:335610-335831 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References