Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4172523..4173142 Replicon chromosome
Accession NZ_CP054750
Organism Klebsiella pneumoniae strain KP20194c3

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HUS03_RS20735 Protein ID WP_002892050.1
Coordinates 4172924..4173142 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HUS03_RS20730 Protein ID WP_002892066.1
Coordinates 4172523..4172897 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS03_RS20720 4167675..4168868 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HUS03_RS20725 4168891..4172037 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
HUS03_RS20730 4172523..4172897 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HUS03_RS20735 4172924..4173142 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HUS03_RS20740 4173301..4173867 + 567 WP_002892030.1 maltose O-acetyltransferase -
HUS03_RS20745 4173839..4173979 - 141 WP_004147370.1 hypothetical protein -
HUS03_RS20750 4174000..4174470 + 471 WP_002892026.1 YlaC family protein -
HUS03_RS20755 4174445..4175896 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HUS03_RS20760 4175997..4176695 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HUS03_RS20765 4176692..4176832 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HUS03_RS20770 4176832..4177095 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T160263 WP_002892050.1 NZ_CP054750:4172924-4173142 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T160263 NZ_CP070421:85763-86068 [Klebsiella quasipneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCTGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT160263 WP_002892066.1 NZ_CP054750:4172523-4172897 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT160263 NZ_CP070421:85543-85761 [Klebsiella quasipneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGTGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References