160249

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 4874..5454 Replicon plasmid pKP20194c4-p4
Accession NZ_CP054748
Organism Klebsiella pneumoniae strain KP20194c4

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag HUS04_RS29280 Protein ID WP_071177730.1
Coordinates 4874..5188 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag HUS04_RS29285 Protein ID WP_000093040.1
Coordinates 5176..5454 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS04_RS29255 818..2782 + 1965 WP_071177727.1 TraM recognition domain-containing protein -
HUS04_RS29260 2782..3513 + 732 WP_071177728.1 replication-relaxation family protein -
HUS04_RS29265 3520..4050 + 531 WP_071177729.1 hypothetical protein -
HUS04_RS29270 4077..4256 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
HUS04_RS29275 4282..4710 - 429 WP_001140599.1 hypothetical protein -
HUS04_RS29280 4874..5188 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUS04_RS29285 5176..5454 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
HUS04_RS29290 5788..5994 - 207 Protein_7 TonB family protein -
HUS04_RS29295 5991..6362 - 372 WP_001237044.1 cell envelope integrity protein TolA -
HUS04_RS29300 6636..6881 - 246 WP_032440458.1 hypothetical protein -
HUS04_RS29305 7526..9013 + 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11971 11971


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T160249 WP_071177730.1 NZ_CP054748:c5188-4874 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

>T160249 NZ_CP070415:1926083-1926185 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT160249 WP_000093040.1 NZ_CP054748:c5454-5176 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp

>AT160249 NZ_CP070415:c1926192-1926047 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References