Detailed information of TA system TA160237

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5047278..5048959
• Replicon: chromosome
• Accession: NZ_CP054744
• Organism: Klebsiella pneumoniae strain KP20194c4

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: W8V1Q6
• Locus tag: HUS04_RS24970
• Protein ID: WP_002885155.1
• Coordinates: 5047278..5048195 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: W8UPQ8
• Locus tag: HUS04_RS24975
• Protein ID: WP_004151732.1
• Coordinates: 5048201..5048959 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUS04_RS24950	5042584..5044104	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
HUS04_RS24955	5044101..5045099	+	999	WP_002885172.1	ribose ABC transporter permease	-
HUS04_RS24960	5045130..5046071	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
HUS04_RS24965	5046146..5047153	+	1008	WP_004151731.1	carbohydrate kinase family protein	-
HUS04_RS24970	5047278..5048195	-	918	WP_002885155.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HUS04_RS24975	5048201..5048959	-	759	WP_004151732.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
HUS04_RS24980	5049045..5049773	-	729	WP_002885152.1	response regulator transcription factor	-
HUS04_RS24985	5050046..5052193	+	2148	WP_077598858.1	formate dehydrogenase subunit alpha	-
HUS04_RS24990	5052423..5053109	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34687.15 Da
• Isoelectric Point: 5.4707

>T160237 WP_002885155.1 NZ_CP054744:c5048195-5047278 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T160237 NZ_CP070379:c4623381-4622959 [Streptomyces tsukubensis]
GTGAGCGCGGCGCAGTTTCTGATCGACACCAGCGCGCTCGCCCGATTCCTCCGCGGGGACGCCGAGCAGTACGGCTGGGA
CCAGGCAGCAGCAGCCGGGCTCATCGCGACCTGCCCCATCACCGAGCTGGAGTTCTTCTACAGCGCGCGATCAGCCGAGG
ATCGCGCCCGGGGCGTCGAGGATCTGCGGATGATCTTCGGCTGGGTCCCCGTCGACGACCGCGCCTACGATCGCGCCTGG
CAGGTCCAGGAACTGCTGACTCGGCGCGGACAGCACCGCAGCGCCGGCCCGGTTGACCTCGTCGTCGCCGCCACAGCGGA
GTTGCAGGGCCTCACCCTCCTGCACCGCGACCGCGATTTCGACTGCATCGCCGCCGTCACCGGTCAGGCCCTGCAGTGGT
TCGGCCCCGATCCGGGCAAATGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28564.92 Da
• Isoelectric Point: 10.0870

>AT160237 WP_004151732.1 NZ_CP054744:c5048959-5048201 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT160237 NZ_CP070379:c4623593-4623378 [Streptomyces tsukubensis]
ATGAGTCGCACAGTGATCGACCTGGACGACGAGCTGCTTGCCGACGTGGCGCAGGCGCTGGGAACCAGCACCAAGAAGGA
GACGGTCAATACCGCCCTGCGGGAAGTACTGGAGAACCGGCGCCGGGCTCTCGCTCTGGCCCGGCTGCGCGCGGCGGCGG
CCGACGGGGGCTTCGACCTGGACGTCTTCGACGACAAGCAGAGCTACCGGCGGTGA

Structures

Toxin

• AlphaFold DB: A0A0H3GH11

Antitoxin

• AlphaFold DB: A0A0H3GQB5