Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4891094..4891610 Replicon chromosome
Accession NZ_CP054744
Organism Klebsiella pneumoniae strain KP20194c4

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag HUS04_RS24170 Protein ID WP_002886902.1
Coordinates 4891094..4891378 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HUS04_RS24175 Protein ID WP_002886901.1
Coordinates 4891368..4891610 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS04_RS24145 4886578..4886886 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
HUS04_RS24150 4886971..4887144 + 174 WP_002886906.1 hypothetical protein -
HUS04_RS24155 4887147..4887890 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HUS04_RS24160 4888247..4890385 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
HUS04_RS24165 4890626..4891090 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HUS04_RS24170 4891094..4891378 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUS04_RS24175 4891368..4891610 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HUS04_RS24180 4891688..4893598 - 1911 WP_004152270.1 BglG family transcription antiterminator -
HUS04_RS24185 4893621..4894775 - 1155 WP_002886900.1 lactonase family protein -
HUS04_RS24190 4894841..4895581 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T160236 WP_002886902.1 NZ_CP054744:c4891378-4891094 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T160236 NZ_CP070379:3080806-3081069 [Streptomyces tsukubensis]
GTGAGTGAGTACCGAACCGTCTTCTGCCCCGAAGCGCAGGCCGAACTCCGGAAGATCCCCCGCGATATGGCGCTGCGCAT
CCTGGCCAAGCTGACCGAACTGGAGGCCGATCCACTCGGCTTCAGCACCACCGCGCTCGTGTCCCAGCCGGACCGCCGAC
GCCTGCGGATGGGCGACTACCGCGTCGTCTACACGATCGACAATGGAGAGTTGGTGGTTTGGTTCGTTCATGTGGGACAT
CGGTCCACCGTCTACGACACCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT160236 WP_002886901.1 NZ_CP054744:c4891610-4891368 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT160236 NZ_CP070379:3080544-3080813 [Streptomyces tsukubensis]
ATGACACAGCCGCTGCCCATAGAGTCCATCCGTGACGTGCGTGCACATTTGGCGGAGGTCGTGGAGCGCGCGGACCGGGA
CGATGTGCCCACCGTGATCACCCGACGCGGCAAGCAGGTCGCCGCCGTCGTCTCCATCGAGGTGCTGCGCAAATACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCCAACCCGGCTCCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCCCGCGGTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References