Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 79802..80712 Replicon plasmid pKP20194c5-p1
Accession NZ_CP054739
Organism Klebsiella pneumoniae strain KP20194c5

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag HUS05_RS27295 Protein ID WP_004026354.1
Coordinates 79802..80272 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag HUS05_RS27300 Protein ID WP_004026357.1
Coordinates 80269..80712 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS05_RS27255 75118..75432 + 315 WP_011251273.1 hypothetical protein -
HUS05_RS27260 75441..75951 + 511 Protein_81 hypothetical protein -
HUS05_RS27265 75941..76381 + 441 WP_011251275.1 hypothetical protein -
HUS05_RS27270 76806..77762 - 957 WP_011251280.1 DsbA family protein -
HUS05_RS27275 77822..78163 - 342 WP_011251281.1 hypothetical protein -
HUS05_RS27280 78177..78488 - 312 WP_011251282.1 hypothetical protein -
HUS05_RS27285 78505..78939 - 435 Protein_86 thioredoxin fold domain-containing protein -
HUS05_RS27290 78956..79653 - 698 Protein_87 IS1 family transposase -
HUS05_RS27295 79802..80272 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
HUS05_RS27300 80269..80712 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
HUS05_RS27305 80813..81316 - 504 Protein_90 DUF4113 domain-containing protein -
HUS05_RS27310 81522..82502 - 981 WP_000019473.1 IS5-like element ISKpn26 family transposase -
HUS05_RS27315 82568..83875 + 1308 Protein_92 FepA family TonB-dependent siderophore receptor -
HUS05_RS27320 83937..84158 + 222 WP_004213615.1 hypothetical protein -
HUS05_RS27325 84301..85203 - 903 WP_004213613.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 1..195034 195034
- inside IScluster/Tn - iroN / rmpA 73521..93497 19976


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T160212 WP_004026354.1 NZ_CP054739:c80272-79802 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T160212 NZ_CP070338:3832449-3832859 [Mycobacterium tuberculosis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT160212 WP_004026357.1 NZ_CP054739:c80712-80269 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT160212 NZ_CP070338:3832174-3832452 [Mycobacterium tuberculosis]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCTGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References