160205

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4171504..4172123 Replicon chromosome
Accession NZ_CP054738
Organism Klebsiella pneumoniae strain KP20194c5

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HUS05_RS20735 Protein ID WP_002892050.1
Coordinates 4171905..4172123 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HUS05_RS20730 Protein ID WP_002892066.1
Coordinates 4171504..4171878 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS05_RS20720 4166656..4167849 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HUS05_RS20725 4167872..4171018 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
HUS05_RS20730 4171504..4171878 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HUS05_RS20735 4171905..4172123 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HUS05_RS20740 4172282..4172848 + 567 WP_002892030.1 maltose O-acetyltransferase -
HUS05_RS20745 4172820..4172960 - 141 WP_004147370.1 hypothetical protein -
HUS05_RS20750 4172981..4173451 + 471 WP_002892026.1 YlaC family protein -
HUS05_RS20755 4173426..4174877 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HUS05_RS20760 4174978..4175676 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HUS05_RS20765 4175673..4175813 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HUS05_RS20770 4175813..4176076 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T160205 WP_002892050.1 NZ_CP054738:4171905-4172123 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T160205 NZ_CP070338:3661303-3661611 [Mycobacterium tuberculosis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT160205 WP_002892066.1 NZ_CP054738:4171504-4171878 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT160205 NZ_CP070338:3661071-3661316 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References