Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4171140..4171759 Replicon chromosome
Accession NZ_CP054732
Organism Klebsiella pneumoniae strain KP20194d

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HUS06_RS20725 Protein ID WP_002892050.1
Coordinates 4171541..4171759 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HUS06_RS20720 Protein ID WP_002892066.1
Coordinates 4171140..4171514 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUS06_RS20710 4166292..4167485 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HUS06_RS20715 4167508..4170654 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
HUS06_RS20720 4171140..4171514 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HUS06_RS20725 4171541..4171759 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HUS06_RS20730 4171918..4172484 + 567 WP_002892030.1 maltose O-acetyltransferase -
HUS06_RS20735 4172456..4172596 - 141 WP_004147370.1 hypothetical protein -
HUS06_RS20740 4172617..4173087 + 471 WP_002892026.1 YlaC family protein -
HUS06_RS20745 4173062..4174513 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HUS06_RS20750 4174614..4175312 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HUS06_RS20755 4175309..4175449 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HUS06_RS20760 4175449..4175712 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T160175 WP_002892050.1 NZ_CP054732:4171541-4171759 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T160175 NZ_CP070338:1744059-1744307 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT160175 WP_002892066.1 NZ_CP054732:4171140-4171514 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT160175 NZ_CP070338:1743847-1744059 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References