Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 119867..120537 | Replicon | plasmid pKP20194e-p1 |
Accession | NZ_CP054727 | ||
Organism | Klebsiella pneumoniae strain KP20194e |
Toxin (Protein)
Gene name | vagD | Uniprot ID | Q6U619 |
Locus tag | HUS07_RS27530 | Protein ID | WP_004213072.1 |
Coordinates | 119867..120310 (-) | Length | 148 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | Q6U620 |
Locus tag | HUS07_RS27535 | Protein ID | WP_004213073.1 |
Coordinates | 120307..120537 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HUS07_RS27495 | 115278..115553 | + | 276 | WP_004213932.1 | carboxymuconolactone decarboxylase family protein | - |
HUS07_RS27500 | 115616..116107 | + | 492 | WP_011251327.1 | DM13 domain-containing protein | - |
HUS07_RS27505 | 116156..117076 | + | 921 | WP_004213934.1 | DUF1471 domain-containing protein | - |
HUS07_RS27510 | 117167..117573 | + | 407 | Protein_132 | GAF domain-containing protein | - |
HUS07_RS27515 | 118088..118723 | - | 636 | Protein_133 | response regulator | - |
HUS07_RS27520 | 119140..119433 | + | 294 | Protein_134 | transposase | - |
HUS07_RS27525 | 119437..119853 | + | 417 | Protein_135 | restriction endonuclease | - |
HUS07_RS27530 | 119867..120310 | - | 444 | WP_004213072.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
HUS07_RS27535 | 120307..120537 | - | 231 | WP_004213073.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
HUS07_RS27540 | 121145..122278 | + | 1134 | WP_004213075.1 | DUF3800 domain-containing protein | - |
HUS07_RS27545 | 122294..122587 | + | 294 | WP_004213076.1 | hypothetical protein | - |
HUS07_RS27550 | 122577..122783 | - | 207 | WP_004213077.1 | hypothetical protein | - |
HUS07_RS27555 | 123135..123425 | + | 291 | WP_004213078.1 | hypothetical protein | - |
HUS07_RS27560 | 123415..124314 | + | 900 | WP_004225022.1 | nucleotide-binding protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | - | iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..195027 | 195027 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 148 a.a. Molecular weight: 16006.74 Da Isoelectric Point: 9.3642
>T160153 WP_004213072.1 NZ_CP054727:c120310-119867 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
Download Length: 444 bp
>T160153 NZ_CP070327:c2336208-2336044 [Ferrovum myxofaciens]
ATGAGCGTACTCATCGACACCTCGGTGTGGATAGACCACTTCCGCAACGGAAATGATGCGTTGATTGACTTGATCGGGCT
AGACCTCGCGCTGACTCACCCAATGGTCATACTCGAAATTGCGTGCGGGACCCCCCCCAGCGCCACGCATCCAGACACTG
GATAA
ATGAGCGTACTCATCGACACCTCGGTGTGGATAGACCACTTCCGCAACGGAAATGATGCGTTGATTGACTTGATCGGGCT
AGACCTCGCGCTGACTCACCCAATGGTCATACTCGAAATTGCGTGCGGGACCCCCCCCAGCGCCACGCATCCAGACACTG
GATAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8677.73 Da Isoelectric Point: 4.4563
>AT160153 WP_004213073.1 NZ_CP054727:c120537-120307 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT160153 NZ_CP070327:c2336411-2336205 [Ferrovum myxofaciens]
ATGCGTACCACTGTCACTATCGACGATGCACTCTACGAAAAGGCCCTGGAAATGGCCGACCCAAATATGGACAAATCGGA
TATTTTCCGAGAAGCAATCAAGACATTCGTGCGCGTGCAGGCAGCCAAGCGTCTTGCAACTCTAGGCGGCATGATACCCA
AGATTCAGGATGTACCGCGTCGCCGTGAGGAGCCAGTCGTGCAATGA
ATGCGTACCACTGTCACTATCGACGATGCACTCTACGAAAAGGCCCTGGAAATGGCCGACCCAAATATGGACAAATCGGA
TATTTTCCGAGAAGCAATCAAGACATTCGTGCGCGTGCAGGCAGCCAAGCGTCTTGCAACTCTAGGCGGCATGATACCCA
AGATTCAGGATGTACCGCGTCGCCGTGAGGAGCCAGTCGTGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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