Detailed information of TA system TA160100

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): kacAT/ElaA-DUF1778
• Location: 93099..93902
• Replicon: plasmid unnamed1
• Accession: NZ_CP054717
• Organism: Salmonella enterica strain 85-0120

Toxin (Protein)

• Gene name: KacT
• Uniprot ID: -
• Locus tag: HPG84_RS23775
• Protein ID: WP_171774034.1
• Coordinates: 93099..93629 (-)
• Length: 177 a.a.

Antitoxin (Protein)

• Gene name: KacA
• Uniprot ID: -
• Locus tag: HPG84_RS23780
• Protein ID: WP_171774033.1
• Coordinates: 93633..93902 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPG84_RS23730	88360..89142	-	783	WP_071678786.1	site-specific integrase	-
HPG84_RS23735	89155..89690	-	536	Protein_101	cytoplasmic protein	-
HPG84_RS23740	89687..89977	-	291	WP_057394649.1	cytoplasmic protein	-
HPG84_RS23745	89979..90284	-	306	WP_001159874.1	type II toxin-antitoxin system toxin CcdB	-
HPG84_RS23750	90286..90504	-	219	WP_000813642.1	type II toxin-antitoxin system antitoxin CcdA	-
HPG84_RS23755	91216..91830	+	615	WP_171774035.1	DNA-binding protein	-
HPG84_RS23760	92001..92231	+	231	WP_174896800.1	hypothetical protein	-
HPG84_RS23765	92262..92567	+	306	WP_174896801.1	cytoplasmic protein	-
HPG84_RS23770	92867..93098	-	232	Protein_108	transposase	-
HPG84_RS23775	93099..93629	-	531	WP_171774034.1	GNAT family N-acetyltransferase	Toxin
HPG84_RS23780	93633..93902	-	270	WP_171774033.1	DUF1778 domain-containing protein	Antitoxin
HPG84_RS23785	94756..95748	+	993	WP_077907168.1	RepB family plasmid replication initiator protein	-
HPG84_RS23790	96052..96156	-	105	Protein_112	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..162029	162029

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 177 a.a.
• Molecular weight: 26068.27 Da
• Isoelectric Point: 5.5500

>T160100 WP_171774034.1 NZ_CP054717:c93629-93099 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFF

Nucleotide

• Length: 531 bp

>T160100 NZ_CP070292:4004543-4004695 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 13263.91 Da
• Isoelectric Point: 5.5500

>AT160100 WP_171774033.1 NZ_CP054717:c93902-93633 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFF

Nucleotide

• Length: 270 bp

>AT160100 NZ_CP070292:c4004494-4004437 [Escherichia albertii]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA