Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 89979..90504 Replicon plasmid unnamed1
Accession NZ_CP054717
Organism Salmonella enterica strain 85-0120

Toxin (Protein)


Gene name ccdB Uniprot ID I3VZQ7
Locus tag HPG84_RS23745 Protein ID WP_001159874.1
Coordinates 89979..90284 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID I3VZQ6
Locus tag HPG84_RS23750 Protein ID WP_000813642.1
Coordinates 90286..90504 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPG84_RS23715 85517..85792 + 276 WP_174896799.1 hypothetical protein -
HPG84_RS23720 85821..85955 - 135 Protein_98 transposase -
HPG84_RS23725 87161..87856 - 696 WP_000389613.1 CPBP family intramembrane metalloprotease -
HPG84_RS23730 88360..89142 - 783 WP_071678786.1 site-specific integrase -
HPG84_RS23735 89155..89690 - 536 Protein_101 cytoplasmic protein -
HPG84_RS23740 89687..89977 - 291 WP_057394649.1 cytoplasmic protein -
HPG84_RS23745 89979..90284 - 306 WP_001159874.1 type II toxin-antitoxin system toxin CcdB Toxin
HPG84_RS23750 90286..90504 - 219 WP_000813642.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
HPG84_RS23755 91216..91830 + 615 WP_171774035.1 DNA-binding protein -
HPG84_RS23760 92001..92231 + 231 WP_174896800.1 hypothetical protein -
HPG84_RS23765 92262..92567 + 306 WP_174896801.1 cytoplasmic protein -
HPG84_RS23770 92867..93098 - 232 Protein_108 transposase -
HPG84_RS23775 93099..93629 - 531 WP_171774034.1 GNAT family N-acetyltransferase -
HPG84_RS23780 93633..93902 - 270 WP_171774033.1 DUF1778 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..162029 162029


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-88)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T160099 WP_001159874.1 NZ_CP054717:c90284-89979 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T160099 NZ_CP070292:c3719019-3718678 [Escherichia albertii]
ATGTGGGACGTCGAGACAACGGAGACTTTCGACAACTGGTTTGATGCCCAGACTGTTGCGCTGAAAGAAGATTTGCTTGC
TGCAATGCTGATTCTTGCAGAGTATGGCCCACAGTTGGGCAGACCCTTTGCGGACACGGTTAATGATTCACAGTTTTCAA
ATATGAAAGAATTACGCGTCCAACATCAGGGAAACCCGGTACGTGCTTTTTTTGCTTTCGATCCTGCGCGCCGTGGCATT
GTATTATGTGCAGGTGATAAAACGGGGTTAAATGAGAAAAAGTTTTATCGCGATATGATCAAGCTCGCTGATTCTGAATA
CCGTAAGCATCTGAAAAAGTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT160099 WP_000813642.1 NZ_CP054717:c90504-90286 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT160099 NZ_CP070292:c3718668-3718369 [Escherichia albertii]
ATGGCTACTCTAAAAGAACTGATGGCAAAGCAAAGCCCTGAAAGCCAGGCGCGTATTGCGGCAAAAGTTGAGGAAATGCG
CCAGACCATCGCCTTGCATCAGCTGAGAGAAGAACTCAATATTTCGCAAACGGAAATGGCGGCAGCGATGGGCATTAAGC
AACCGACCCTTGCAAAAATGGAGCAGGCAGATAACGATCCTCGGTTGTCTACGCTAAAACGCTATGTTGCGGCTTTAGGT
GGGGAATTGAGTATCGACGTTAAACTGCCTAATGGTAAGAGAGTTGCATTTCAGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A600Z065

Antitoxin

Source ID Structure
AlphaFold DB A0A600YYQ0

References