Detailed information of TA system TA160098

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 68748..69270
• Replicon: plasmid unnamed1
• Accession: NZ_CP054717
• Organism: Salmonella enterica strain 85-0120

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HPG84_RS23610
• Protein ID: WP_174896784.1
• Coordinates: 68989..69270 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G3CAG1
• Locus tag: HPG84_RS23605
• Protein ID: WP_000121743.1
• Coordinates: 68748..68999 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPG84_RS23575	64384..64614	+	231	WP_097456349.1	DNA partition complex ParG	-
HPG84_RS23580	64630..64938	+	309	WP_174896780.1	CopG family transcriptional regulator	-
HPG84_RS23585	64963..65940	+	978	WP_174896781.1	hypothetical protein	-
HPG84_RS23590	65937..66326	-	390	WP_189672012.1	DNA distortion polypeptide 3	-
HPG84_RS23595	66449..66892	-	444	WP_174896783.1	hypothetical protein	-
HPG84_RS23600	66901..67797	-	897	WP_174896831.1	replication initiation protein	-
HPG84_RS23605	68748..68999	+	252	WP_000121743.1	plasmid stabilization protein	Antitoxin
HPG84_RS23610	68989..69270	+	282	WP_174896784.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HPG84_RS23615	69415..69738	+	324	WP_174896785.1	hypothetical protein	-
HPG84_RS23620	69783..70028	+	246	WP_174896786.1	hypothetical protein	-
HPG84_RS23625	70018..70233	+	216	WP_174896787.1	hypothetical protein	-
HPG84_RS23630	70326..70655	+	330	WP_174896788.1	hypothetical protein	-
HPG84_RS23635	70698..70868	+	171	WP_174896789.1	hypothetical protein	-
HPG84_RS23640	71108..71380	+	273	WP_174896790.1	hypothetical protein	-
HPG84_RS23645	71637..71711	+	75	Protein_83	DNA distortion polypeptide 3	-
HPG84_RS23650	71706..72251	+	546	WP_174896832.1	DNA distortion polypeptide 1	-
HPG84_RS23655	72254..73414	+	1161	WP_174896791.1	spore coat protein CotH	-
HPG84_RS23660	73768..73932	+	165	Protein_86	transcription termination factor NusG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..162029	162029

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-117)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 12066.38 Da
• Isoelectric Point: 12.7685

>T160098 WP_174896784.1 NZ_CP054717:68989-69270 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Nucleotide

• Length: 282 bp

>T160098 NZ_CP070292:3530673-3530891 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACACTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT160098 WP_000121743.1 NZ_CP054717:68748-68999 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Nucleotide

• Length: 252 bp

>AT160098 NZ_CP070292:3530273-3530647 [Escherichia albertii]
ATAGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A3S5I301