Detailed information of TA system TA160095

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 3940192..3940763
• Replicon: chromosome
• Accession: NZ_CP054705
• Organism: Salicibibacter cibarius strain NKC5-3

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: HUG15_RS19870
• Protein ID: WP_200125109.1
• Coordinates: 3940192..3940527 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: HUG15_RS19875
• Protein ID: WP_200129070.1
• Coordinates: 3940524..3940763 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUG15_RS19835	3936207..3936977	+	771	WP_200125094.1	hypothetical protein	-
HUG15_RS19840	3937451..3937909	+	459	WP_200125097.1	hypothetical protein	-
HUG15_RS19845	3938016..3938216	-	201	WP_200125099.1	hypothetical protein	-
HUG15_RS19850	3938420..3938878	-	459	WP_211202283.1	Fic family protein	-
HUG15_RS19855	3938856..3939059	-	204	WP_200125103.1	hypothetical protein	-
HUG15_RS19860	3939265..3939447	-	183	WP_200125105.1	hypothetical protein	-
HUG15_RS19865	3939806..3940042	-	237	WP_200125107.1	helix-turn-helix domain-containing protein	-
HUG15_RS19870	3940192..3940527	-	336	WP_200125109.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HUG15_RS19875	3940524..3940763	-	240	WP_200129070.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HUG15_RS19880	3941343..3941702	+	360	WP_200125111.1	hypothetical protein	-
HUG15_RS19885	3942053..3942703	+	651	WP_200125113.1	hypothetical protein	-
HUG15_RS19890	3943336..3944010	-	675	WP_200125115.1	hypothetical protein	-
HUG15_RS19895	3944634..3944861	-	228	WP_200125117.1	superinfection immunity protein	-
HUG15_RS19900	3945035..3945226	-	192	WP_200125119.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-106)

Antitoxin

• Antitoxin PemI-like (1-79)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12697.71 Da
• Isoelectric Point: 9.5616

>T160095 WP_200125109.1 NZ_CP054705:c3940527-3940192 [Salicibibacter cibarius]
VRTVPEKGDLVYLNFHPQSGREQAGHRPAIILSPKSFNQVTDLAIVCQITKQKKGYPFEVELPKGLKIRGSILTDHVKSI
DWQSRQIQIVEEAPQNVTETCIKRIHTFMYL

Nucleotide

• Length: 336 bp

>T160095 NZ_CP070292:2178350-2178452 [Escherichia albertii]
GCAAGGCAACTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAACA
GGAATCGTTTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8934.07 Da
• Isoelectric Point: 4.2950

>AT160095 WP_200129070.1 NZ_CP054705:c3940763-3940524 [Salicibibacter cibarius]
MSSKIQRWGNSLGVRIPHKLAKNVSIYDGSEVEMIEEQNGILIRPIDAAPTLDELLSQVTDENKPDFIDWGQPEGKEVW

Nucleotide

• Length: 240 bp

>AT160095 NZ_CP070292:c2178454-2178222 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTCAGTTGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT