Detailed information of TA system TA160094

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 69755..70314
• Replicon: plasmid unnamed3
• Accession: NZ_CP054704
• Organism: Vibrio alginolyticus strain GS_MYPK1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A347UR22
• Locus tag: HUO05_RS25665
• Protein ID: WP_005398411.1
• Coordinates: 70036..70314 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HUO05_RS25660
• Protein ID: WP_176311810.1
• Coordinates: 69755..70039 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUO05_RS25615	64797..64997	+	201	WP_176311803.1	hypothetical protein	-
HUO05_RS25620	65092..65595	+	504	WP_176311804.1	Fe3+-citrate ABC transporter substrate-binding protein	-
HUO05_RS25625	65742..65975	+	234	WP_176311805.1	hypothetical protein	-
HUO05_RS25630	66049..66447	+	399	WP_176311806.1	hypothetical protein	-
HUO05_RS25635	66706..66858	+	153	WP_176311807.1	hypothetical protein	-
HUO05_RS25640	67047..67232	+	186	WP_176311808.1	DUF4236 domain-containing protein	-
HUO05_RS25645	67444..68238	-	795	WP_176311847.1	restriction endonuclease	-
HUO05_RS25650	68418..68987	-	570	WP_176311809.1	PIN domain-containing protein	-
HUO05_RS25655	68987..69439	-	453	WP_142547844.1	helix-turn-helix domain-containing protein	-
HUO05_RS25660	69755..70039	+	285	WP_176311810.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HUO05_RS25665	70036..70314	+	279	WP_005398411.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HUO05_RS25670	70343..70468	-	126	WP_081007929.1	DUF3265 domain-containing protein	-
HUO05_RS25675	70458..70865	-	408	WP_176225793.1	hypothetical protein	-
HUO05_RS25680	70895..70987	-	93	WP_171359434.1	DUF3265 domain-containing protein	-
HUO05_RS25685	71002..71544	-	543	WP_031813962.1	hypothetical protein	-
HUO05_RS25690	71572..71685	-	114	WP_081008368.1	DUF3265 domain-containing protein	-
HUO05_RS25695	71699..72100	-	402	WP_023585550.1	HIT family protein	-
HUO05_RS25700	72240..73112	-	873	WP_005390110.1	hypothetical protein	-
HUO05_RS25705	73122..73259	-	138	WP_171343485.1	DUF3265 domain-containing protein	-
HUO05_RS25710	73229..73639	-	411	WP_080607102.1	cytidine deaminase	-
HUO05_RS25715	73789..74346	-	558	WP_158156617.1	hypothetical protein	-
HUO05_RS25720	74380..74490	-	111	WP_017420369.1	DUF3265 domain-containing protein	-
HUO05_RS25725	74487..75017	-	531	WP_176311037.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..121537	121537
	-	inside	Integron	-	-	67444..75017	7573

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10891.57 Da
• Isoelectric Point: 4.3430

>T160094 WP_005398411.1 NZ_CP054704:70036-70314 [Vibrio alginolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T160094 NZ_CP070292:c1475760-1474435 [Escherichia albertii]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11055.37 Da
• Isoelectric Point: 9.2167

>AT160094 WP_176311810.1 NZ_CP054704:69755-70039 [Vibrio alginolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARVRNRGKQ

Nucleotide

• Length: 285 bp

>AT160094 NZ_CP070292:c1476058-1475765 [Escherichia albertii]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Structures

Toxin

• AlphaFold DB: A0A347UR22