160093

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 68418..69439 Replicon plasmid unnamed3
Accession NZ_CP054704
Organism Vibrio alginolyticus strain GS_MYPK1

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag HUO05_RS25650 Protein ID WP_176311809.1
Coordinates 68418..68987 (-) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag HUO05_RS25655 Protein ID WP_142547844.1
Coordinates 68987..69439 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUO05_RS25605 63695..64153 + 459 WP_064369724.1 hypothetical protein -
HUO05_RS25610 64153..64782 + 630 WP_054866453.1 tyrosine-type recombinase/integrase -
HUO05_RS25615 64797..64997 + 201 WP_176311803.1 hypothetical protein -
HUO05_RS25620 65092..65595 + 504 WP_176311804.1 Fe3+-citrate ABC transporter substrate-binding protein -
HUO05_RS25625 65742..65975 + 234 WP_176311805.1 hypothetical protein -
HUO05_RS25630 66049..66447 + 399 WP_176311806.1 hypothetical protein -
HUO05_RS25635 66706..66858 + 153 WP_176311807.1 hypothetical protein -
HUO05_RS25640 67047..67232 + 186 WP_176311808.1 DUF4236 domain-containing protein -
HUO05_RS25645 67444..68238 - 795 WP_176311847.1 restriction endonuclease -
HUO05_RS25650 68418..68987 - 570 WP_176311809.1 PIN domain-containing protein Toxin
HUO05_RS25655 68987..69439 - 453 WP_142547844.1 helix-turn-helix domain-containing protein Antitoxin
HUO05_RS25660 69755..70039 + 285 WP_176311810.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
HUO05_RS25665 70036..70314 + 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
HUO05_RS25670 70343..70468 - 126 WP_081007929.1 DUF3265 domain-containing protein -
HUO05_RS25675 70458..70865 - 408 WP_176225793.1 hypothetical protein -
HUO05_RS25680 70895..70987 - 93 WP_171359434.1 DUF3265 domain-containing protein -
HUO05_RS25685 71002..71544 - 543 WP_031813962.1 hypothetical protein -
HUO05_RS25690 71572..71685 - 114 WP_081008368.1 DUF3265 domain-containing protein -
HUO05_RS25695 71699..72100 - 402 WP_023585550.1 HIT family protein -
HUO05_RS25700 72240..73112 - 873 WP_005390110.1 hypothetical protein -
HUO05_RS25705 73122..73259 - 138 WP_171343485.1 DUF3265 domain-containing protein -
HUO05_RS25710 73229..73639 - 411 WP_080607102.1 cytidine deaminase -
HUO05_RS25715 73789..74346 - 558 WP_158156617.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..121537 121537
- inside Integron - - 67444..75017 7573


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

Helix-turn-helix domain, group 17

(80-125)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21595.05 Da        Isoelectric Point: 5.3332

>T160093 WP_176311809.1 NZ_CP054704:c68987-68418 [Vibrio alginolyticus]
MSSYTVILDACVMYPAPLRSYLMYLACTGLYRARWTNQIHDEWIRNLIKNNPELDPEKLKRTRELMDKSVPGCLIEGYEP
LINGLTLPDVDDRHVVAAAIKGQAESIITFNLKDFPKEELEPLELSAIHPDEFLCDMFELNASACITAAQQQRRSLKNPQ
MSAEEFLACLQKQKLPSFVSKMKQFQAIL

Download         Length: 570 bp

>T160093 NZ_CP070292:1196320-1196631 [Escherichia albertii]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTAGGTGGGAACAACCTAAGGGTGATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16031.29 Da        Isoelectric Point: 4.6229

>AT160093 WP_142547844.1 NZ_CP054704:c69439-68987 [Vibrio alginolyticus]
MSIATKLPSAEEIALARLGSQELSAVLETNGEAQTINVIDKSGKTHEVTIPASALNLMIEVLTQLGQGNSVSITPIHAEL
TTQEGADLLNVSRPTFIKLLDSGVIPFTRSGNRRKVAFADVMAHKKQLEEESLATLADLSALDQEMGMGY

Download         Length: 453 bp

>AT160093 NZ_CP070292:1196628-1197047 [Escherichia albertii]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGACGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGTGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCAGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGCCAGATCTTGTCTGGACAACGATCCTTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References