Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1423349..1423896 Replicon chromosome
Accession NZ_CP054700
Organism Vibrio alginolyticus strain GS_MYPK1

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR19
Locus tag HUO05_RS06380 Protein ID WP_025548916.1
Coordinates 1423349..1423651 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag HUO05_RS06385 Protein ID WP_005448240.1
Coordinates 1423639..1423896 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUO05_RS06335 1419119..1419274 - 156 WP_081007967.1 DUF3265 domain-containing protein -
HUO05_RS06340 1419226..1419657 - 432 WP_042524345.1 DUF1851 domain-containing protein -
HUO05_RS06345 1419816..1420139 - 324 WP_038217934.1 hypothetical protein -
HUO05_RS06350 1420282..1420995 - 714 WP_176311023.1 hypothetical protein -
HUO05_RS06355 1421050..1421166 - 117 WP_080277002.1 DUF3265 domain-containing protein -
HUO05_RS06360 1421157..1421555 - 399 WP_025539256.1 hypothetical protein -
HUO05_RS06365 1421751..1421999 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HUO05_RS06370 1421989..1422279 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin -
HUO05_RS06375 1422407..1423171 - 765 WP_053350854.1 ATP-binding protein -
HUO05_RS06380 1423349..1423651 - 303 WP_025548916.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUO05_RS06385 1423639..1423896 - 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HUO05_RS06390 1424069..1425040 - 972 WP_021822411.1 hypothetical protein -
HUO05_RS06395 1425077..1425190 - 114 WP_134648620.1 DUF3265 domain-containing protein -
HUO05_RS06400 1425204..1425605 - 402 WP_029807766.1 HIT family protein -
HUO05_RS06405 1425638..1425754 - 117 WP_080277002.1 DUF3265 domain-containing protein -
HUO05_RS06410 1425745..1426143 - 399 WP_048626546.1 hypothetical protein -
HUO05_RS06415 1426172..1426303 - 132 WP_176311290.1 DUF3265 domain-containing protein -
HUO05_RS06420 1426300..1426602 - 303 WP_064354072.1 type II toxin-antitoxin system RelE/ParE family toxin -
HUO05_RS06425 1426590..1426847 - 258 WP_021458101.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HUO05_RS06430 1427047..1427646 - 600 WP_176311024.1 hypothetical protein -
HUO05_RS06435 1427741..1427851 - 111 WP_080936724.1 DUF3265 domain-containing protein -
HUO05_RS06440 1427855..1428190 - 336 WP_042524632.1 TonB family protein -
HUO05_RS06445 1428424..1428663 + 240 WP_176311025.1 RNA-binding protein -
HUO05_RS06450 1428737..1428852 - 116 Protein_1248 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1416893..1487842 70949
- inside Integron - - 1417444..1454443 36999


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11669.57 Da        Isoelectric Point: 5.1765

>T160089 WP_025548916.1 NZ_CP054700:c1423651-1423349 [Vibrio alginolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T160089 NZ_CP070292:c253961-253659 [Escherichia albertii]
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACACAAAAA
GATACCTTCTGATATTCATATTACATTGTTGCGGAAGCTGGATATTATCAATGCCGCAACTACTTGGAAGGACTTGAGAT
CACCACCAGGTAATCGGTATGAGGAATTGTCAGGGAAGCTAAACGGCTATTCATCAATAAGGGTGAATAATCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT160089 WP_005448240.1 NZ_CP054700:c1423896-1423639 [Vibrio alginolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT160089 NZ_CP070292:c253587-253249 [Escherichia albertii]
ATGAAACAGGCAACCAGAAAACCGACGACTGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTTAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGCAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGACCTGTGG
GAAGTTGAAAATGATATGCGCGTTCAGGAAGAGTTAAGCCGTATCACTACTGCTGAAGAATTTATTTCTCAGCGGAATCT
GAATAAAAAAGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR19

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References