Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1421751..1422279 Replicon chromosome
Accession NZ_CP054700
Organism Vibrio alginolyticus strain GS_MYPK1

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag HUO05_RS06370 Protein ID WP_005377002.1
Coordinates 1421989..1422279 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag HUO05_RS06365 Protein ID WP_005377003.1
Coordinates 1421751..1421999 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUO05_RS06315 1416893..1417258 + 366 WP_025998596.1 hypothetical protein -
HUO05_RS06320 1417444..1417980 - 537 WP_025769035.1 nucleotidyltransferase family protein -
HUO05_RS06325 1418006..1418128 - 123 WP_158156579.1 DUF3265 domain-containing protein -
HUO05_RS06330 1418125..1419084 - 960 WP_017821423.1 phosphotransferase -
HUO05_RS06335 1419119..1419274 - 156 WP_081007967.1 DUF3265 domain-containing protein -
HUO05_RS06340 1419226..1419657 - 432 WP_042524345.1 DUF1851 domain-containing protein -
HUO05_RS06345 1419816..1420139 - 324 WP_038217934.1 hypothetical protein -
HUO05_RS06350 1420282..1420995 - 714 WP_176311023.1 hypothetical protein -
HUO05_RS06355 1421050..1421166 - 117 WP_080277002.1 DUF3265 domain-containing protein -
HUO05_RS06360 1421157..1421555 - 399 WP_025539256.1 hypothetical protein -
HUO05_RS06365 1421751..1421999 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HUO05_RS06370 1421989..1422279 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUO05_RS06375 1422407..1423171 - 765 WP_053350854.1 ATP-binding protein -
HUO05_RS06380 1423349..1423651 - 303 WP_025548916.1 type II toxin-antitoxin system RelE/ParE family toxin -
HUO05_RS06385 1423639..1423896 - 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
HUO05_RS06390 1424069..1425040 - 972 WP_021822411.1 hypothetical protein -
HUO05_RS06395 1425077..1425190 - 114 WP_134648620.1 DUF3265 domain-containing protein -
HUO05_RS06400 1425204..1425605 - 402 WP_029807766.1 HIT family protein -
HUO05_RS06405 1425638..1425754 - 117 WP_080277002.1 DUF3265 domain-containing protein -
HUO05_RS06410 1425745..1426143 - 399 WP_048626546.1 hypothetical protein -
HUO05_RS06415 1426172..1426303 - 132 WP_176311290.1 DUF3265 domain-containing protein -
HUO05_RS06420 1426300..1426602 - 303 WP_064354072.1 type II toxin-antitoxin system RelE/ParE family toxin -
HUO05_RS06425 1426590..1426847 - 258 WP_021458101.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1416893..1487842 70949
- inside Integron - - 1417444..1454443 36999


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T160088 WP_005377002.1 NZ_CP054700:1421989-1422279 [Vibrio alginolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T160088 NZ_CP070292:155063-155248 [Escherichia albertii]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT160088 WP_005377003.1 NZ_CP054700:1421751-1421999 [Vibrio alginolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT160088 NZ_CP070292:155265-155675 [Escherichia albertii]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGGGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTTCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCAAAAAGATTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCGGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References