Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1383479..1384007 Replicon chromosome
Accession NZ_CP054700
Organism Vibrio alginolyticus strain GS_MYPK1

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag HUO05_RS06180 Protein ID WP_005377002.1
Coordinates 1383717..1384007 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag HUO05_RS06175 Protein ID WP_005377003.1
Coordinates 1383479..1383727 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUO05_RS06140 1379118..1379519 - 402 WP_054579579.1 DUF2007 domain-containing protein -
HUO05_RS06145 1379623..1380144 - 522 WP_054579580.1 GNAT family N-acetyltransferase -
HUO05_RS06150 1380325..1380891 + 567 WP_054579581.1 hypothetical protein -
HUO05_RS06155 1380951..1381127 - 177 WP_170897320.1 DUF3265 domain-containing protein -
HUO05_RS06160 1381159..1382130 + 972 WP_176311014.1 IS30 family transposase -
HUO05_RS06165 1382153..1382518 - 366 WP_042524341.1 hypothetical protein -
HUO05_RS06170 1382686..1383285 - 600 WP_176311015.1 hypothetical protein -
HUO05_RS06175 1383479..1383727 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HUO05_RS06180 1383717..1384007 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUO05_RS06185 1384026..1384142 - 117 WP_017821452.1 DUF3265 domain-containing protein -
HUO05_RS06190 1384133..1384996 - 864 WP_176311016.1 ATP-binding protein -
HUO05_RS06195 1385392..1385892 + 501 WP_176311017.1 MFS transporter -
HUO05_RS06200 1385859..1386077 - 219 Protein_1198 IS200/IS605 family transposase -
HUO05_RS06205 1386187..1386882 - 696 WP_017821449.1 4'-phosphopantetheinyl transferase superfamily protein -
HUO05_RS06210 1387097..1387246 - 150 WP_017634313.1 hypothetical protein -
HUO05_RS06215 1387250..1387538 - 289 Protein_1201 transposase -
HUO05_RS06220 1387783..1388859 + 1077 WP_017634314.1 3-deoxy-7-phosphoheptulonate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1371797..1399181 27384
- inside IScluster/Tn - - 1381198..1386077 4879


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T160087 WP_005377002.1 NZ_CP054700:1383717-1384007 [Vibrio alginolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T160087 NZ_CP070291:66445-66825 [Escherichia albertii]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGACTGCCGGGCATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTCCAGGCCAGAGTTGTGTACGAAGAGATCACCGACCTTTTCGAAG
TATCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
TGAAATCGCCGTATCTTCAGTCGCAGAAAAGCTACGTGAACTATATGGTTCCAAGACTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT160087 WP_005377003.1 NZ_CP054700:1383479-1383727 [Vibrio alginolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT160087 NZ_CP070291:66224-66445 [Escherichia albertii]
ATGCAGTCTATTAACTTCCGTACCGCACGCGGCAACCTTAGCGAAGTGCTCAATAATGTTGAAGCAGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAATCAGCCGTAATTGTCAGCAAGGCCACTTTCGAAGCCTATAAAAAAGCGGCGCTGGATG
CCGAATTTGCATCCCTGTTTGACACTCTGGACTCCACTAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References