Detailed information of TA system TA160086

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2933571..2934105
• Replicon: chromosome
• Accession: NZ_CP054699
• Organism: Candidatus Contubernalis alkalaceticum strain Z-7904

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HUE98_RS14525
• Protein ID: WP_241421329.1
• Coordinates: 2933571..2933843 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HUE98_RS14530
• Protein ID: WP_241421330.1
• Coordinates: 2933836..2934105 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUE98_RS14515 (HUE98_14565)	2931251..2931523	-	273	WP_241421327.1	NHLP leader peptide family RiPP precursor	-
HUE98_RS14520 (HUE98_14570)	2932196..2933233	+	1038	WP_241421328.1	NAD(P)/FAD-dependent oxidoreductase	-
HUE98_RS14525 (HUE98_14575)	2933571..2933843	-	273	WP_241421329.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HUE98_RS14530 (HUE98_14580)	2933836..2934105	-	270	WP_241421330.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HUE98_RS14535 (HUE98_14585)	2934430..2935386	-	957	WP_241421331.1	alpha/beta hydrolase	-
HUE98_RS14540 (HUE98_14590)	2935646..2936521	-	876	WP_241421332.1	AraC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-87)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10637.52 Da
• Isoelectric Point: 9.6749

>T160086 WP_241421329.1 NZ_CP054699:c2933843-2933571 [Candidatus Contubernalis alkalaceticum]
MLKIRYSSRFKKDFKTIIKRGYDVKLFEEVLRLLVEEKPLSAKYLDHPLVGSYGGHRECHITPDWLLIYKIEKDILTLSL
TRIGTHSDLF

Nucleotide

• Length: 273 bp

>T160086 NZ_CP070290:3827773-3828114 [Escherichia albertii]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCACCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAGTTTATTGGGGTAATTAC
AGGTAAACAGAAAGTCGCCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10102.47 Da
• Isoelectric Point: 4.5859

>AT160086 WP_241421330.1 NZ_CP054699:c2934105-2933836 [Candidatus Contubernalis alkalaceticum]
MAKTTNLNIRVDEELKRQAEAIFSELGLNMSTAMNMFLRYSVRYGGIPFDLRIEKPNAETMAAIDDVNNNRNMSKSFDSV
DALMEDLHA

Nucleotide

• Length: 270 bp

>AT160086 NZ_CP070290:c3827778-3827702 [Escherichia albertii]
AGTCATGATTACTATTCTCCATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT