Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1652457..1653040 Replicon chromosome
Accession NZ_CP054699
Organism Candidatus Contubernalis alkalaceticum strain Z-7904

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HUE98_RS08140 Protein ID WP_241423338.1
Coordinates 1652696..1653040 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HUE98_RS08135 Protein ID WP_241423337.1
Coordinates 1652457..1652696 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE98_RS08100 (HUE98_08125) 1648299..1648532 - 234 Protein_1602 radical SAM protein -
HUE98_RS08105 (HUE98_08130) 1648875..1649057 + 183 WP_241423331.1 TetR/AcrR family transcriptional regulator -
HUE98_RS08110 (HUE98_08135) 1649249..1649827 - 579 WP_241423332.1 N-acetylmuramoyl-L-alanine amidase -
HUE98_RS08115 (HUE98_08140) 1649933..1650073 - 141 WP_241423333.1 hypothetical protein -
HUE98_RS17610 1650255..1650386 - 132 WP_277623715.1 hypothetical protein -
HUE98_RS08120 (HUE98_08145) 1650462..1650863 - 402 WP_241423334.1 PIN domain-containing protein -
HUE98_RS08125 (HUE98_08150) 1650851..1651123 - 273 WP_241423335.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HUE98_RS08130 (HUE98_08155) 1651969..1652286 - 318 WP_241423336.1 hypothetical protein -
HUE98_RS08135 (HUE98_08160) 1652457..1652696 + 240 WP_241423337.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HUE98_RS08140 (HUE98_08165) 1652696..1653040 + 345 WP_241423338.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HUE98_RS08145 (HUE98_08170) 1653293..1654927 - 1635 WP_241421052.1 IS1634 family transposase -
HUE98_RS08150 (HUE98_08175) 1655447..1655821 + 375 WP_241423339.1 type II toxin-antitoxin system RelE/ParE family toxin -
HUE98_RS08155 (HUE98_08180) 1655876..1656163 + 288 WP_241420515.1 transposase -
HUE98_RS08160 (HUE98_08185) 1656235..1657062 + 828 WP_241420516.1 IS3 family transposase -
HUE98_RS08165 (HUE98_08190) 1657336..1657620 + 285 WP_241423529.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1639992..1659845 19853


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-101)

Antitoxin

SpoVT-AbrB domain

(6-50)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12917.89 Da        Isoelectric Point: 5.7274

>T160085 WP_241423338.1 NZ_CP054699:1652696-1653040 [Candidatus Contubernalis alkalaceticum]
MAYIPEQGDIILLEFNPQAGHEQKGRRPAVVISNNTFNRFTRIAIVCPVTKTDRKFPLHVSLDNRTKTSGVVLCEQVKSL
DISARDTVFLEKAPRDILEEIIDILFGFVEIFSD

Download         Length: 345 bp

>T160085 NZ_CP070290:3753278-3753430 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9117.50 Da        Isoelectric Point: 9.5770

>AT160085 WP_241423337.1 NZ_CP054699:1652457-1652696 [Candidatus Contubernalis alkalaceticum]
MYTTIQKWGNSQAVRLPKAILELAKIQEKDRVELKVENGSIIIRPVKKHKSLKERIAEHNGDYECSEWDTGKPAGKEVW

Download         Length: 240 bp

>AT160085 NZ_CP070290:c3753229-3753172 [Escherichia albertii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References