Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 954676..955316 Replicon chromosome
Accession NZ_CP054699
Organism Candidatus Contubernalis alkalaceticum strain Z-7904

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag HUE98_RS04590 Protein ID WP_277623706.1
Coordinates 954951..955316 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HUE98_RS04585 Protein ID WP_241422689.1
Coordinates 954676..954948 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE98_RS04570 (HUE98_04595) 950793..952007 + 1215 WP_241422686.1 cofactor-independent phosphoglycerate mutase -
HUE98_RS04575 (HUE98_04600) 952028..953260 + 1233 WP_241422687.1 aspartate kinase -
HUE98_RS04580 (HUE98_04605) 953408..954595 + 1188 WP_241422688.1 alanine racemase -
HUE98_RS04585 (HUE98_04610) 954676..954948 + 273 WP_241422689.1 ribbon-helix-helix protein, CopG family Antitoxin
HUE98_RS04590 (HUE98_04615) 954951..955316 + 366 WP_277623706.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HUE98_RS04595 (HUE98_04620) 955541..956137 + 597 WP_241422690.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
HUE98_RS04600 (HUE98_04625) 956505..958082 + 1578 WP_241422691.1 phosphoglycerate dehydrogenase -
HUE98_RS04605 (HUE98_04630) 958119..958325 + 207 WP_241422692.1 zinc ribbon domain-containing protein -
HUE98_RS04610 (HUE98_04635) 958479..959108 + 630 WP_241422693.1 DUF1614 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-118)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-42)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13595.75 Da        Isoelectric Point: 7.0167

>T160084 WP_277623706.1 NZ_CP054699:954951-955316 [Candidatus Contubernalis alkalaceticum]
MVENKVDVKRGNIFYADLSPVVGSEQGGVRPVLVIQNDIGNKYSPTVIIAAITSQIEKAKLPTHVEIESKNNQLDKDSVI
LLEQIRTIDKQRLREKVTNLDEKIMVRVNEALRISLGLIDF

Download         Length: 366 bp

>T160084 NZ_CP070290:3316277-3316495 [Escherichia albertii]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTCTGCGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
TATCGAGAAAAATAAATATGAATTATCAGATAATGAATTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTTGCAGAGC
TGACTATGAATAAGCTATATGACAAGATCCCTTCCTCAGTGTGGAAATTCATTCGGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10504.11 Da        Isoelectric Point: 5.2290

>AT160084 WP_241422689.1 NZ_CP054699:954676-954948 [Candidatus Contubernalis alkalaceticum]
MAETRRIMISLPSNLLQEVDGIVATEKRTRSEFIREAMKLYLHERKKRYIRERMQKGYMEMAQLNLTLANEALEAENEAD
DLAEQMVSGV

Download         Length: 273 bp

>AT160084 NZ_CP070290:3315877-3316251 [Escherichia albertii]
ATGGATGAATACTCACCAAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGTAACCATGGCTGGGTAAATGACCCAACCTCGGCAATCAATCTACAGCTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAACAGATTGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAACCGATT
GTTCCGTTGCTTTGTTAACGCCACCAAAGCGAATCCTGCAAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References