Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 837335..837921 Replicon chromosome
Accession NZ_CP054699
Organism Candidatus Contubernalis alkalaceticum strain Z-7904

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HUE98_RS04060 Protein ID WP_241422591.1
Coordinates 837335..837685 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HUE98_RS04065 Protein ID WP_241422592.1
Coordinates 837679..837921 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUE98_RS04045 (HUE98_04070) 833058..833642 + 585 WP_241422588.1 VTT domain-containing protein -
HUE98_RS04050 (HUE98_04075) 833912..836626 - 2715 WP_241422589.1 PAS domain S-box protein -
HUE98_RS04055 (HUE98_04080) 837141..837287 + 147 WP_241422590.1 hypothetical protein -
HUE98_RS04060 (HUE98_04085) 837335..837685 - 351 WP_241422591.1 endoribonuclease MazF Toxin
HUE98_RS04065 (HUE98_04090) 837679..837921 - 243 WP_241422592.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HUE98_RS04070 (HUE98_04095) 838035..838187 + 153 Protein_796 molybdopterin biosynthesis protein -
HUE98_RS04075 (HUE98_04100) 838552..839712 + 1161 WP_241422593.1 IPT/TIG domain-containing protein -
HUE98_RS04080 (HUE98_04105) 839825..840733 + 909 WP_241422594.1 DUF4825 domain-containing protein -
HUE98_RS04085 (HUE98_04110) 841063..841305 + 243 WP_241422595.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin

Antitoxin PemI-like

(3-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13234.58 Da        Isoelectric Point: 9.1723

>T160083 WP_241422591.1 NZ_CP054699:c837685-837335 [Candidatus Contubernalis alkalaceticum]
MVKLKKYFPQRGDIVWLNFSPQTGHEQAGKRPAVCISPKEYNKKVGLAIFCPITSQVKGYPFEVILPKDCPVKGVILSDQ
VKNLDWSDRNVEFICTLPEDKLVEVLYKLEALIRRG

Download         Length: 351 bp

>T160083 NZ_CP070290:2312214-2312492 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCTGCAAGCAGTCTTGTTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACGTTTGAGTTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9160.61 Da        Isoelectric Point: 10.1345

>AT160083 WP_241422592.1 NZ_CP054699:c837921-837679 [Candidatus Contubernalis alkalaceticum]
VILQIKKWGNSLALRIPKSFAKEINLDTGTKINLTIENGKLIIEPLKQNKYKLNDLLSEVNENNIHSEYSTGKPRGKEIW

Download         Length: 243 bp

>AT160083 NZ_CP070290:2312492-2312776 [Escherichia albertii]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTTGCGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References