Detailed information of TA system TA160082

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 6692491..6693001
• Replicon: chromosome
• Accession: NZ_CP054698
• Organism: Nostoc edaphicum CCNP1411

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HUN01_RS31025
• Protein ID: WP_181929380.1
• Coordinates: 6692491..6692769 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HUN01_RS31030
• Protein ID: WP_181932892.1
• Coordinates: 6692759..6693001 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUN01_RS30995	6688565..6689425	-	861	WP_181929375.1	PD-(D/E)XK nuclease family protein	-
HUN01_RS31000	6689573..6691003	+	1431	WP_181929376.1	phosphoglucomutase/phosphomannomutase family protein	-
HUN01_RS31005	6691154..6691432	+	279	WP_181929377.1	LapA family protein	-
HUN01_RS31010	6691446..6691699	+	254	Protein_5580	DUF433 domain-containing protein	-
HUN01_RS31015	6691722..6691979	+	258	WP_181929378.1	BrnA antitoxin family protein	-
HUN01_RS31020	6692014..6692457	+	444	WP_181929379.1	DUF29 domain-containing protein	-
HUN01_RS31025	6692491..6692769	-	279	WP_181929380.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HUN01_RS31030	6692759..6693001	-	243	WP_181932892.1	ribbon-helix-helix protein, CopG family	Antitoxin
HUN01_RS31035	6693185..6693589	-	405	WP_181929381.1	hypothetical protein	-
HUN01_RS31040	6694111..6694398	+	288	WP_181929382.1	BrnT family toxin	-
HUN01_RS31045	6694367..6694645	+	279	WP_181932893.1	hypothetical protein	-
HUN01_RS31050	6694799..6694999	+	201	WP_181929383.1	type II toxin-antitoxin system HicB family antitoxin	-
HUN01_RS31055	6694996..6695205	+	210	WP_181929384.1	type II toxin-antitoxin system HicA family toxin	-
HUN01_RS31060	6695370..6696074	-	705	WP_181929385.1	hypothetical protein	-
HUN01_RS31065	6696225..6696947	-	723	WP_181932894.1	Uma2 family endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-88)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-42)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10786.51 Da
• Isoelectric Point: 10.0180

>T160082 WP_181929380.1 NZ_CP054698:c6692769-6692491 [Nostoc edaphicum CCNP1411]
MQIKWLRRALRNLEQAHSYILKENPQAAQEVILKIQLAASQLENYPFMGRTGRIEGTRELVVSGTPYIVIYRVKEESVEI
LRVFHTSKRYPD

Nucleotide

• Length: 279 bp

>T160082 NZ_CP070290:2289668-2290054 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTCATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGAC
TGACCCCGGCAGAGCACAGGCGTTGATTTATCGCGTGCAGAATCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCATCCGTATCCGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8935.88 Da
• Isoelectric Point: 4.0941

>AT160082 WP_181932892.1 NZ_CP054698:c6693001-6692759 [Nostoc edaphicum CCNP1411]
MSKENITFRIDSNQKAALDAIAAGMNRDRSYVLNEAVATYLEMYQWQIEEIQKGIAEADAGDFASDEEVKATFARLTNAD

Nucleotide

• Length: 243 bp

>AT160082 NZ_CP070290:2289450-2289671 [Escherichia albertii]
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCTGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTGACTGATCGATGA