Detailed information of TA system TA160080

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/DUF433(antitoxin)
• Location: 4959078..4959637
• Replicon: chromosome
• Accession: NZ_CP054698
• Organism: Nostoc edaphicum CCNP1411

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HUN01_RS23670
• Protein ID: WP_181928229.1
• Coordinates: 4959078..4959416 (-)
• Length: 113 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HUN01_RS23675
• Protein ID: WP_181928230.1
• Coordinates: 4959413..4959637 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUN01_RS23625	4954443..4955600	-	1158	WP_181928223.1	extracellular solute-binding protein	-
HUN01_RS23630	4956088..4956459	+	372	WP_181928224.1	hypothetical protein	-
HUN01_RS23635	4956773..4957243	+	471	WP_203219498.1	DUF29 domain-containing protein	-
HUN01_RS23640	4957251..4957460	-	210	Protein_4126	type II toxin-antitoxin system HicA family toxin	-
HUN01_RS23645	4957457..4957660	-	204	WP_181928226.1	type II toxin-antitoxin system HicB family antitoxin	-
HUN01_RS23650	4957834..4958190	-	357	WP_181928227.1	DUF5615 family PIN-like protein	-
HUN01_RS23655	4958187..4958360	-	174	WP_181932958.1	hypothetical protein	-
HUN01_RS23660	4958357..4958569	-	213	WP_181928228.1	hypothetical protein	-
HUN01_RS23665	4958690..4959010	-	321	Protein_4131	hypothetical protein	-
HUN01_RS23670	4959078..4959416	-	339	WP_181928229.1	DUF5615 family PIN-like protein	Toxin
HUN01_RS23675	4959413..4959637	-	225	WP_181928230.1	DUF433 domain-containing protein	Antitoxin
HUN01_RS23680	4959673..4959989	-	317	Protein_4134	hypothetical protein	-
HUN01_RS23685	4960034..4960372	-	339	Protein_4135	type II toxin-antitoxin system RelE/ParE family toxin	-
HUN01_RS23690	4960356..4960619	-	264	WP_181928231.1	hypothetical protein	-
HUN01_RS23695	4960703..4960966	-	264	WP_181928232.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HUN01_RS23700	4960963..4961175	-	213	WP_181928233.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Domain of unknown function DUF5615 (1-78)

Antitoxin

• Protein of unknown function DUF433 (8-63)

Sequences

Toxin

Protein

• Length: 113 a.a.
• Molecular weight: 12298.14 Da
• Isoelectric Point: 4.2450

>T160080 WP_181928229.1 NZ_CP054698:c4959416-4959078 [Nostoc edaphicum CCNP1411]
MTIWVDAHLSPAIATWISHTFGITALALRDVGLRDAEDLEIFEAAKAQGVILITKDSDFVDLVERLGTPPQIIWLTCGNT
SNARLQEILNATLLQALELLRTGETLVEISKD

Nucleotide

• Length: 339 bp

>T160080 NZ_CP054698:c4959416-4959078 [Nostoc edaphicum CCNP1411]
ATGACAATCTGGGTAGATGCACATTTATCCCCTGCGATCGCAACTTGGATCAGCCATACTTTTGGTATAACAGCTTTAGC
TTTACGTGATGTTGGTCTGAGAGATGCTGAAGACCTTGAGATTTTTGAGGCAGCAAAAGCTCAAGGAGTTATCTTGATAA
CCAAGGATAGCGATTTTGTTGACTTGGTTGAGCGTTTGGGAACACCACCGCAGATTATCTGGTTAACTTGCGGAAACACA
TCAAATGCTCGGTTGCAAGAAATTTTAAATGCCACTTTGCTACAAGCACTAGAACTTTTACGAACAGGTGAAACGTTAGT
CGAAATCAGCAAAGACTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8205.62 Da
• Isoelectric Point: 6.9475

>AT160080 WP_181928230.1 NZ_CP054698:c4959637-4959413 [Nostoc edaphicum CCNP1411]
MSDLLRRITVNPKQCSGRPCIRGMRIRVSDVLDLFAAGLSAEQILEEMPDLEADDLKAALLYASRKLNHPVLVA

Nucleotide

• Length: 225 bp

>AT160080 NZ_CP054698:c4959637-4959413 [Nostoc edaphicum CCNP1411]
ATGTCAGACTTACTTAGAAGAATTACAGTTAATCCCAAACAATGTAGTGGTCGCCCATGCATTCGGGGCATGAGAATTCG
GGTATCAGATGTACTGGACTTGTTTGCTGCGGGACTTAGTGCAGAACAAATTTTAGAAGAAATGCCTGATCTTGAAGCCG
ACGATCTCAAAGCAGCACTACTATATGCTTCGCGGAAGCTTAATCATCCAGTGTTAGTAGCATGA