Detailed information of TA system TA160078

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 3699524..3700060
• Replicon: chromosome
• Accession: NZ_CP054698
• Organism: Nostoc edaphicum CCNP1411

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: HUN01_RS18115
• Protein ID: WP_181932413.1
• Coordinates: 3699524..3699823 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: HUN01_RS18120
• Protein ID: WP_181932414.1
• Coordinates: 3699827..3700060 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUN01_RS34915	3695956..3697887	+	1932	WP_203219542.1	DMT family transporter	-
HUN01_RS18100	3698025..3698294	-	270	WP_181932410.1	hypothetical protein	-
HUN01_RS18105	3698808..3699188	-	381	WP_181932411.1	clan AA aspartic protease	-
HUN01_RS18110	3699185..3699457	-	273	WP_181932412.1	hypothetical protein	-
HUN01_RS18115	3699524..3699823	-	300	WP_181932413.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HUN01_RS18120	3699827..3700060	-	234	WP_181932414.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
HUN01_RS18125	3700281..3700550	-	270	WP_181932415.1	hypothetical protein	-
HUN01_RS18130	3700498..3700836	-	339	WP_181932416.1	hypothetical protein	-
HUN01_RS18135	3701149..3702537	+	1389	WP_181932417.1	putative DNA binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-91)

Antitoxin

• Antitoxin ParD (1-75)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11928.35 Da
• Isoelectric Point: 6.3240

>T160078 WP_181932413.1 NZ_CP054698:c3699823-3699524 [Nostoc edaphicum CCNP1411]
MSAFRLTELATQDLLSIGRYTQKTWGTEQRNRYLAILDDCFHLLAQERHRGRTCDDIRSGYRNYHIGRHLIFYQETTETI
DIIRILHDRMDVESYFNED

Nucleotide

• Length: 300 bp

>T160078 NZ_CP070290:635029-635343 [Escherichia albertii]
ATGCACCTGATCACTCAAAAAGCATTGAAAGATGCAGCGGAAAAATATCCGCAGCATAAAACGGAGTTGGTGGCACTGGG
GAACACGATTGCTAAGGGATACTTCAAAAAACCTGAGTCATTAAAAGCAGTGTTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCACAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8455.42 Da
• Isoelectric Point: 4.5822

>AT160078 WP_181932414.1 NZ_CP054698:c3700060-3699827 [Nostoc edaphicum CCNP1411]
MQKNTSVTLGEHFEAFIANQVDSGRFASASEAIRAGLRLLEEREIKLAALQRALRDGENSGFADYSLSGLLAELDRE

Nucleotide

• Length: 234 bp

>AT160078 NZ_CP070290:635340-635756 [Escherichia albertii]
ATGATTGCGATTGCCGATATCTTGCAAGCAGGAGAAAAGCTAACCGATGTGGCACCTTTTCTGGCGGGTATCCAGAGCGA
AGAACAGTATGCCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAATCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCTGAATTTAATGCGATGGTTCAAGCCATGCCTGGCGGT
GTTGCTGTGATTCGTACCCTGATGGATCAATACGGCTTAACCCTTTCCGATCTTCCAGAAATTGGCAGTAAATCCATGGT
GTCACGCGTTTTGAACGGGAAGAGAAAATTAACGCTGGAACACGCTAAAAAACTGGCAGCGCGATTCGGCATTTCCCCTG
CGTTGTTTATTGATTAA