Detailed information of TA system TA160076

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 1863869..1864578
• Replicon: chromosome
• Accession: NZ_CP054698
• Organism: Nostoc edaphicum CCNP1411

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: HUN01_RS10465
• Protein ID: WP_181931214.1
• Coordinates: 1863869..1864255 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: HUN01_RS10470
• Protein ID: WP_181931215.1
• Coordinates: 1864252..1864578 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUN01_RS10445	1859384..1859646	+	263	Protein_1532	flagellar assembly protein H	-
HUN01_RS10450	1859749..1861149	-	1401	WP_181931211.1	cyclic nucleotide-binding domain-containing protein	-
HUN01_RS10455	1861497..1863161	-	1665	WP_181931212.1	FAD-dependent oxidoreductase	-
HUN01_RS10460	1863284..1863499	-	216	WP_181931213.1	hypothetical protein	-
HUN01_RS10465	1863869..1864255	+	387	WP_181931214.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HUN01_RS10470	1864252..1864578	+	327	WP_181931215.1	helix-turn-helix domain-containing protein	Antitoxin
HUN01_RS10475	1864526..1864717	-	192	Protein_1538	tyrosine-type recombinase/integrase	-
HUN01_RS10480	1865521..1867860	+	2340	WP_181931216.1	response regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (17-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (43-82)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14167.98 Da
• Isoelectric Point: 5.9114

>T160076 WP_181931214.1 NZ_CP054698:1863869-1864255 [Nostoc edaphicum CCNP1411]
MSKTHQKPLKYIASALDDLKDFPEDVQDVMGYALDLAQHGGKHPDAKPLHGFKGGGVLEVVDDFDGDTYRAVYTVKFAGF
VYLLHAFQKKSKHGIATSQQDIDLVKKSLKAAQEDYLEEAAKEKGVDE

Nucleotide

• Length: 387 bp

>T160076 NZ_CP070290:297556-298083 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTATATCCTTTGTAGCAACACTC
CAGAACGTCAGGTCCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCGTTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACTAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12168.83 Da
• Isoelectric Point: 8.5171

>AT160076 WP_181931215.1 NZ_CP054698:1864252-1864578 [Nostoc edaphicum CCNP1411]
VTKENSVYTSSGNVFSDLGLPNSEERLVKAELARKISESITFRNLTQVQAAELLGIDQPKVSALVRGRLSGFSIDRLFQF
LNDLDNDVEIIIKRKPEDRKQARTTVVY

Nucleotide

• Length: 327 bp

>AT160076 NZ_CP070290:297283-297549 [Escherichia albertii]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAATCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGTTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA