Detailed information of TA system TA160075

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 1152078..1152718
• Replicon: chromosome
• Accession: NZ_CP054698
• Organism: Nostoc edaphicum CCNP1411

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HUN01_RS07570
• Protein ID: WP_181930753.1
• Coordinates: 1152078..1152476 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HUN01_RS07575
• Protein ID: WP_181930754.1
• Coordinates: 1152476..1152718 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUN01_RS07540	1148969..1149700	-	732	WP_181930749.1	hypothetical protein	-
HUN01_RS07545	1150279..1150701	-	423	WP_181930750.1	hypothetical protein	-
HUN01_RS07550	1150942..1151145	+	204	WP_099103703.1	hypothetical protein	-
HUN01_RS07555	1151156..1151563	+	408	WP_181930751.1	hypothetical protein	-
HUN01_RS07560	1151604..1151813	+	210	WP_181930752.1	type II toxin-antitoxin system HicB family antitoxin	-
HUN01_RS07565	1151817..1152038	+	222	Protein_961	type II toxin-antitoxin system HicA family toxin	-
HUN01_RS07570	1152078..1152476	-	399	WP_181930753.1	type II toxin-antitoxin system VapC family toxin	Toxin
HUN01_RS07575	1152476..1152718	-	243	WP_181930754.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HUN01_RS07580	1152920..1154587	+	1668	WP_181930755.1	DUF262 domain-containing protein	-
HUN01_RS07585	1154676..1156271	-	1596	WP_181930756.1	nickel-dependent hydrogenase large subunit	-
HUN01_RS07590	1156550..1157512	-	963	WP_181930757.1	hydrogenase small subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (4-128)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-43)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14830.26 Da
• Isoelectric Point: 5.0599

>T160075 WP_181930753.1 NZ_CP054698:c1152476-1152078 [Nostoc edaphicum CCNP1411]
VKLLLDTQCWLWWFTQPELLNEAAIAHIADERNELWLSVASIWEMGIKVAIGKLPLADPLDSYISSRMTVLAMRSLEITA
AHALQAAALPLHHRDPFDRMLIAQAQIGNMTLVSADSMFNQYDISLLWAAKS

Nucleotide

• Length: 399 bp

>T160075 NZ_CP070290:166407-166559 [Escherichia albertii]
ATGCCGCAGAAATATAGATTGCTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGGGATTC
ACTGTGTGAATTGCATATTAAACAGGGGAGTTATGAGCTGGCGGCGTTTTTAGCCTGCAATTTGAAAGAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8830.12 Da
• Isoelectric Point: 5.8021

>AT160075 WP_181930754.1 NZ_CP054698:c1152718-1152476 [Nostoc edaphicum CCNP1411]
METVNIHQAKTNLSKLLSRVELGEEIIISNRGIPIAKLVPFRTSSNRLNSLGQDKGRFVVPNDFNAPLPEEILVAFEGGE

Nucleotide

• Length: 243 bp

>AT160075 NZ_CP070290:c166350-166302 [Escherichia albertii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG