Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 1036369..1036946 Replicon chromosome
Accession NZ_CP054698
Organism Nostoc edaphicum CCNP1411

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HUN01_RS07080 Protein ID WP_181930680.1
Coordinates 1036369..1036632 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HUN01_RS07085 Protein ID WP_181930681.1
Coordinates 1036617..1036946 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUN01_RS07045 1031526..1031999 - 474 WP_181930674.1 MarR family transcriptional regulator -
HUN01_RS07050 1032019..1032873 - 855 WP_181930675.1 ABC transporter permease -
HUN01_RS07055 1032830..1033681 - 852 WP_181930676.1 ATP-binding cassette domain-containing protein -
HUN01_RS07060 1033928..1034416 - 489 WP_181930677.1 DUF3368 domain-containing protein -
HUN01_RS07065 1034413..1034658 - 246 WP_181930678.1 UPF0175 family protein -
HUN01_RS07070 1034842..1035909 + 1068 WP_181930679.1 DUF4935 domain-containing protein -
HUN01_RS07075 1035989..1036237 + 249 WP_181932597.1 DUF4926 domain-containing protein -
HUN01_RS07080 1036369..1036632 + 264 WP_181930680.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
HUN01_RS07085 1036617..1036946 + 330 WP_181930681.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
HUN01_RS07090 1037087..1038112 - 1026 Protein_865 IS4 family transposase -
HUN01_RS07095 1038206..1038883 - 678 Protein_866 SAM-dependent methyltransferase -
HUN01_RS07100 1039579..1039788 + 210 WP_012406943.1 DUF2997 domain-containing protein -
HUN01_RS07105 1039828..1040214 + 387 WP_012406942.1 DUF1257 domain-containing protein -
HUN01_RS07110 1040214..1040675 + 462 WP_181930682.1 ferredoxin -
HUN01_RS07115 1040804..1041088 - 285 WP_069069207.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

SpoVT-AbrB domain

(10-49)

Antitoxin

mRNA interferase PemK-like

(7-107)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9946.22 Da        Isoelectric Point: 4.6742

>T160073 WP_181930680.1 NZ_CP054698:1036369-1036632 [Nostoc edaphicum CCNP1411]
MGTAIRTRIVKIGNSQGIRIPKLLLEQSGIGEEVEIEIQDCHLIVRAASKSRKGWDEAFSTMAKQHDDALLDDTVTTEWE
HVEWEWQ

Download         Length: 264 bp

>T160073 NZ_CP070289:83912-84292 [Escherichia albertii]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGCCACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12097.01 Da        Isoelectric Point: 5.1209

>AT160073 WP_181930681.1 NZ_CP054698:1036617-1036946 [Nostoc edaphicum CCNP1411]
VGVAVNRFDVFLVNLDPTIGSEIQKTRPCVVISPDEMNKYIATVIVAPMTTKGQSYPTRVTCEFQGKNGQIVLDQIRTVD
KTRLVKKLGQIDPDEQKAVLDTLAEMFAE

Download         Length: 330 bp

>AT160073 NZ_CP070289:83691-83912 [Escherichia albertii]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References