Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4500238..4500833 Replicon chromosome
Accession NZ_CP054665
Organism Escherichia coli strain IGC_EcoliInv_1.1

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag HUR94_RS21995 Protein ID WP_000239577.1
Coordinates 4500483..4500833 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag HUR94_RS21990 Protein ID WP_001223208.1
Coordinates 4500238..4500489 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUR94_RS21980 (4495903) 4495903..4499682 + 3780 WP_000060911.1 autotransporter assembly complex protein TamB -
HUR94_RS21985 (4499685) 4499685..4500026 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
HUR94_RS21990 (4500238) 4500238..4500489 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
HUR94_RS21995 (4500483) 4500483..4500833 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
HUR94_RS22000 (4500913) 4500913..4501443 - 531 WP_000055075.1 inorganic diphosphatase -
HUR94_RS22005 (4501753) 4501753..4502709 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
HUR94_RS22010 (4502849) 4502849..4504351 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
HUR94_RS22015 (4504365) 4504365..4505387 + 1023 WP_001313531.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T160067 WP_000239577.1 NZ_CP054665:4500483-4500833 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T160067 NZ_CP070287:3945774-3945926 [Escherichia albertii]
ATGAAGCAGCATAAGGCGATGATTATCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT160067 WP_001223208.1 NZ_CP054665:4500238-4500489 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT160067 NZ_CP070287:c3945725-3945668 [Escherichia albertii]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References