Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2081153..2081984 Replicon chromosome
Accession NZ_CP054665
Organism Escherichia coli strain IGC_EcoliInv_1.1

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag HUR94_RS10430 Protein ID WP_000854814.1
Coordinates 2081610..2081984 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID P76364
Locus tag HUR94_RS10425 Protein ID WP_001285584.1
Coordinates 2081153..2081521 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUR94_RS10410 (2078820) 2078820..2080352 + 1533 WP_001350525.1 protein YeeR -
HUR94_RS10415 (2080349) 2080349..2080795 + 447 WP_000187523.1 RadC family protein -
HUR94_RS10420 (2080858) 2080858..2081079 + 222 WP_000692323.1 DUF987 domain-containing protein -
HUR94_RS10425 (2081153) 2081153..2081521 + 369 WP_001285584.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
HUR94_RS10430 (2081610) 2081610..2081984 + 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
HUR94_RS10435 (2081981) 2081981..2082175 + 195 WP_000988600.1 DUF5983 family protein -
HUR94_RS10440 (2082221) 2082221..2082301 + 81 Protein_2034 hypothetical protein -
HUR94_RS10445 (2082590) 2082590..2082718 - 129 Protein_2035 transposase domain-containing protein -
HUR94_RS10450 (2082838) 2082838..2082972 + 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
HUR94_RS10455 (2083073) 2083073..2083402 - 330 WP_000450409.1 DUF496 family protein -
HUR94_RS10460 (2083574) 2083574..2084632 - 1059 WP_001200891.1 FUSC family protein -
HUR94_RS10465 (2084830) 2084830..2085303 - 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
HUR94_RS10470 (2085422) 2085422..2086588 - 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T160055 WP_000854814.1 NZ_CP054665:2081610-2081984 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T160055 NZ_CP070286:11430-11708 [Escherichia albertii]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13651.52 Da        Isoelectric Point: 5.9541

>AT160055 WP_001285584.1 NZ_CP054665:2081153-2081521 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT160055 NZ_CP070286:11161-11430 [Escherichia albertii]
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAACGCGGTGATGTGCTTCCCCATAACATGGTCGAATCCTCCGCTGCTGCATGGCGGGAT
GAGATGAGCAGGAAGATTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
PDB 2H28
AlphaFold DB A0A1M2E8G6

References