Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1514103..1514741 Replicon chromosome
Accession NZ_CP054665
Organism Escherichia coli strain IGC_EcoliInv_1.1

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag HUR94_RS07540 Protein ID WP_000813794.1
Coordinates 1514103..1514279 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HUR94_RS07545 Protein ID WP_001270286.1
Coordinates 1514325..1514741 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUR94_RS07520 (1509722) 1509722..1510936 - 1215 WP_001326689.1 BenE family transporter YdcO -
HUR94_RS07525 (1510989) 1510989..1511525 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
HUR94_RS07530 (1511598) 1511598..1513559 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HUR94_RS07535 (1513651) 1513651..1513881 - 231 WP_000494244.1 YncJ family protein -
HUR94_RS07540 (1514103) 1514103..1514279 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HUR94_RS07545 (1514325) 1514325..1514741 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HUR94_RS07550 (1514820) 1514820..1516226 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
HUR94_RS07555 (1516471) 1516471..1517616 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
HUR94_RS07560 (1517634) 1517634..1518647 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
HUR94_RS07565 (1518648) 1518648..1519589 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T160044 WP_000813794.1 NZ_CP054665:1514103-1514279 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T160044 NZ_CP070284:1612450-1612836 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTCATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGAC
TGACCCCGGCAGAGCACAGGCGTTGATTTATCGCGTGCAGAATCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCATCCGTATCCGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT160044 WP_001270286.1 NZ_CP054665:1514325-1514741 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT160044 NZ_CP070284:1612232-1612453 [Escherichia albertii]
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCAGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTAATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTGACTGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References