Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 473129..473747 Replicon chromosome
Accession NZ_CP054665
Organism Escherichia coli strain IGC_EcoliInv_1.1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HUR94_RS02335 Protein ID WP_001291435.1
Coordinates 473129..473347 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HUR94_RS02340 Protein ID WP_000344800.1
Coordinates 473373..473747 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUR94_RS02300 (468418) 468418..468990 + 573 WP_000779842.1 YbaY family lipoprotein -
HUR94_RS02305 (469021) 469021..469332 - 312 WP_000409911.1 MGMT family protein -
HUR94_RS02315 (469711) 469711..470064 + 354 WP_000878140.1 DUF1428 domain-containing protein -
HUR94_RS02320 (470106) 470106..471656 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HUR94_RS02325 (471820) 471820..472290 - 471 WP_000136192.1 YlaC family protein -
HUR94_RS02330 (472406) 472406..472957 - 552 WP_000102564.1 maltose O-acetyltransferase -
HUR94_RS02335 (473129) 473129..473347 - 219 WP_001291435.1 HHA domain-containing protein Toxin
HUR94_RS02340 (473373) 473373..473747 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HUR94_RS02345 (474293) 474293..477442 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
HUR94_RS02350 (477465) 477465..478658 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T160033 WP_001291435.1 NZ_CP054665:c473347-473129 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T160033 NZ_CP070282:97885-98172 [Escherichia albertii]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAACTGGACAAGACTATTCAACAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGTGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGTGAAAGAATGAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT160033 WP_000344800.1 NZ_CP054665:c473747-473373 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT160033 NZ_CP070282:97637-97888 [Escherichia albertii]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAATCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGACTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TCGATGCCCTAGACGATCAGGAGCTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGACCTGGAT
AAATACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References