Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 20129..20654 Replicon plasmid unnamed1
Accession NZ_CP054663
Organism Escherichia coli strain IGC_RcoliRes_1.1

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag HUR93_RS25775 Protein ID WP_032334755.1
Coordinates 20349..20654 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag HUR93_RS25770 Protein ID WP_032334753.1
Coordinates 20129..20347 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUR93_RS25745 (17333) 17333..18232 - 900 Protein_16 IS110 family transposase -
HUR93_RS25750 (18320) 18320..18667 + 348 WP_032334749.1 DUF6404 family protein -
HUR93_RS25755 (18685) 18685..19275 - 591 WP_032334750.1 hypothetical protein -
HUR93_RS25760 (19275) 19275..19532 - 258 WP_000371885.1 hypothetical protein -
HUR93_RS25765 (19760) 19760..20002 + 243 Protein_20 hypothetical protein -
HUR93_RS25770 (20129) 20129..20347 + 219 WP_032334753.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
HUR93_RS25775 (20349) 20349..20654 + 306 WP_032334755.1 type II toxin-antitoxin system toxin CcdB Toxin
HUR93_RS25780 (20655) 20655..21461 + 807 WP_061892142.1 site-specific integrase -
HUR93_RS25785 (22264) 22264..22454 - 191 Protein_24 hypothetical protein -
HUR93_RS25790 (22977) 22977..23891 + 915 WP_073972117.1 transcriptional regulator TdcA -
HUR93_RS25795 (23931) 23931..25100 - 1170 WP_000656436.1 M20 family metallopeptidase -
HUR93_RS25800 (25116) 25116..25577 - 462 WP_237897982.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..108557 108557
- flank IS/Tn - - 17333..18187 854


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11678.46 Da        Isoelectric Point: 6.4663

>T160026 WP_032334755.1 NZ_CP054663:20349-20654 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRDLYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T160026 NZ_CP070281:2375903-2376181 [Escherichia albertii]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTATTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCATTAAGCGGCGATCGCGATGGCATCTGGGCAATATCTGTATCAGGCAACTGGCGAATCACATTTGAGTTCGTCAAT
GGCAATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8342.27 Da        Isoelectric Point: 4.5203

>AT160026 WP_032334753.1 NZ_CP054663:20129-20347 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSATMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp

>AT160026 NZ_CP070281:2376181-2376465 [Escherichia albertii]
ATGAAAATGGTCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTGAACGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGACTGTTGACCGGAAAAGCGGCTTTGACGCCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCTGAG
AAAACGGTGGATGTGTCGCGGTTGCGCCGTCTGGTTACGCAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References