Detailed information of TA system TA160023

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4726368..4727203
• Replicon: chromosome
• Accession: NZ_CP054662
• Organism: Escherichia coli strain IGC_RcoliRes_1.1

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HUR93_RS23150
• Protein ID: WP_061892626.1
• Coordinates: 4726826..4727203 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: HUR93_RS23145
• Protein ID: WP_061892627.1
• Coordinates: 4726368..4726736 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HUR93_RS23110 (4722229)	4722229..4722909	+	681	WP_061892478.1	WYL domain-containing protein	-
HUR93_RS23115 (4723057)	4723057..4723734	+	678	WP_061892477.1	hypothetical protein	-
HUR93_RS23120 (4723740)	4723740..4723973	+	234	WP_001278287.1	DUF905 family protein	-
HUR93_RS23125 (4724072)	4724072..4724890	+	819	WP_061892476.1	DUF932 domain-containing protein	-
HUR93_RS23130 (4724945)	4724945..4725430	+	486	WP_061892475.1	antirestriction protein	-
HUR93_RS23135 (4725445)	4725445..4725921	+	477	WP_237897938.1	RadC family protein	-
HUR93_RS23140 (4725984)	4725984..4726205	+	222	WP_000692303.1	DUF987 domain-containing protein	-
HUR93_RS23145 (4726368)	4726368..4726736	+	369	WP_061892627.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HUR93_RS23150 (4726826)	4726826..4727203	+	378	WP_061892626.1	TA system toxin CbtA family protein	Toxin
HUR93_RS23155 (4727200)	4727200..4727688	+	489	WP_039005229.1	DUF5983 family protein	-
HUR93_RS23160 (4727708)	4727708..4727905	+	198	WP_000445282.1	DUF957 domain-containing protein	-
HUR93_RS23165 (4727990)	4727990..4728832	+	843	Protein_4535	DUF4942 domain-containing protein	-
HUR93_RS23170 (4729581)	4729581..4731119	+	1539	WP_001187170.1	lysine decarboxylation/transport transcriptional activator CadC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4710840..4738932	28092

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14361.35 Da
• Isoelectric Point: 8.7492

>T160023 WP_061892626.1 NZ_CP054662:4726826-4727203 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPRF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKR

Nucleotide

• Length: 378 bp

>T160023 NZ_CP070281:1018649-1018801 [Escherichia albertii]
ATGCTAACAAAATATGCCCTTGTGGCAATCATAGTGCTGTGTTGTACAGTGCTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13900.58 Da
• Isoelectric Point: 6.3165

>AT160023 WP_061892627.1 NZ_CP054662:4726368-4726736 [Escherichia coli]
VSDTHHETNYPDDYNNRPWWGQPCTITPCFGARLVQEGNRLYYPADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT160023 NZ_CP070281:c1018607-1018555 [Escherichia albertii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT