Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2608350..2608876 Replicon chromosome
Accession NZ_CP054662
Organism Escherichia coli strain IGC_RcoliRes_1.1

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HUR93_RS12940 Protein ID WP_000323025.1
Coordinates 2608589..2608876 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HUR93_RS12935 Protein ID WP_000534858.1
Coordinates 2608350..2608589 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUR93_RS12895 (2603536) 2603536..2603763 + 228 WP_000476993.1 Cro/CI family transcriptional regulator -
HUR93_RS12900 (2603747) 2603747..2604268 + 522 WP_000705349.1 toxin YdaT family protein -
HUR93_RS12905 (2604249) 2604249..2605214 + 966 WP_000054504.1 hypothetical protein -
HUR93_RS12910 (2605255) 2605255..2605674 + 420 WP_001151195.1 DUF977 family protein -
HUR93_RS12915 (2605729) 2605729..2606778 + 1050 Protein_2533 ISNCY family transposase -
HUR93_RS12920 (2606899) 2606899..2607048 + 150 WP_180302674.1 protein YdfW -
HUR93_RS12925 (2607485) 2607485..2607817 - 333 WP_001317460.1 FlxA-like family protein -
HUR93_RS12930 (2608020) 2608020..2608325 - 306 WP_071527819.1 protein YdfV -
HUR93_RS12935 (2608350) 2608350..2608589 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HUR93_RS12940 (2608589) 2608589..2608876 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HUR93_RS12945 (2608936) 2608936..2609004 + 69 Protein_2539 type I toxin-antitoxin system toxin HokD -
HUR93_RS12950 (2609221) 2609221..2609472 + 252 WP_000980994.1 protein Rem -
HUR93_RS12955 (2609539) 2609539..2609817 + 279 WP_012304870.1 hypothetical protein -
HUR93_RS12960 (2609819) 2609819..2610868 + 1050 WP_053292618.1 DUF968 domain-containing protein -
HUR93_RS12965 (2610881) 2610881..2611237 + 357 WP_000904111.1 RusA family crossover junction endodeoxyribonuclease -
HUR93_RS12970 (2611252) 2611252..2612073 + 822 WP_000762885.1 antitermination protein -
HUR93_RS12985 (2612969) 2612969..2613100 + 132 WP_047626566.1 DUF3927 family protein -
HUR93_RS12990 (2613194) 2613194..2613325 - 132 Protein_2546 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2597059..2650339 53280


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T160017 WP_000323025.1 NZ_CP054662:2608589-2608876 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T160017 NZ_CP070273:c3363756-3362866 [Marinomonas foliarum]
ATGCTCAAAGAAGTCATAAAGCAAATTGTTAACACCAATCCTGAGCATGCAGGGATAACACCTGTTATAGAAAAAGAAAT
ATTGCACCATGATATTATGGCGGTCATGGTAAAACAGGGAGTTATGCAATCACTAACTTTTATTGGCGGCACATCACTTC
GCTTATGCCACAACAGCTCTCGATTATCTGAGGATTTAGATTTTAATGGAGGGCATGACTTTAAACCTGATGACTTTGAT
GGTTTGGAAGTCGAGATTCAAAAATACATACAAAAAAAATATGAAACAGAAGTCTGGGTAAATAAGCCAAACCAAGACAA
ACAAGGAGACACATCTTCTTGGAAAATTAGTATCGAAAAAGAAGCTAACCGCCCTGACCTACCACGTCAAAAAATGCATA
TAGACATTTGTGCTATCCCTTCTTTCGACATTGAGAGAAGACCACTGATAAGTCATTACGATGTCGTCGTTCCGACAGAA
GGACTTTTGATCCCAGTTCAGTCGTTAGAAGAAACCTTGGCAGATAAATTCATTGCTCTAGCATACCGTTCCAGACGTAT
TAAACCTCGTGATGTTTGGGATATTCTTTGGATCAAGCAAAGAGGTATTGACGTATCCATAGAGCTGATCAACAAAAAAC
TTGCGGCAAGAGAAAAAACAAAAGCTAACTTCATAGAGTCGCTTACCCTTCAGGTCGAAAAATTACTCAACGAAGAAGAG
GTAAAAGCCGACTTCAACAACGAAATGAGCCGTTTCATTCCAAGTCAAATTAAACAGCGAACAATTGATAATCCAGAATA
TTGGCAATACGTGCAACTTGAAATTAAAAGCATGACAGACCCGATACTCAAACCTGACTTACAGACAAAGAAATTTGATA
TGGGACTTTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT160017 WP_000534858.1 NZ_CP054662:2608350-2608589 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT160017 NZ_CP070273:c3364282-3363758 [Marinomonas foliarum]
ATGAGTAAAAAAGAAAAACTACTGTCCGTACTATCTGATGCTACTAAAGCTGGTGGCGGTGTTCATACGTCGACAGAAAT
AGCATTTATGCTCGGCGAAAAGCATACCCCTGCCTTTACAAAGTTCCTCACAGATTGCGTAAAAAACGGTGTCTTACGAA
GAGTAGCAACGGGTATTTTTGAAAGTACAATTACTCCGCCTGATGGATCAACGGCCATTTACAAGATTGTAAATAAGCTC
AGAGGAGATGTATTTAACTATATCAGCCTAGAGAGCCAACTTAGCTATACAGGCGATATTTCACAAATTGTTATGGACAG
ACTCACTGTGATGACAAAAGGTAGAAGTGGTATTTTTCCGACACCTTATGGCGTCATTGAGTTTACACATACAAAAAAAA
CGATCGAGACAATCGCTCCTAATATTTATTTCGATTCAGATATAAAAATGTATCGGGCCAAAACAATCCAAGCTCTTATT
GATTTAAAAAACTGTAATCGAAATCTGCACATGCTGGAGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References