Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2092473..2092944 Replicon chromosome
Accession NZ_CP054662
Organism Escherichia coli strain IGC_RcoliRes_1.1

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag HUR93_RS10035 Protein ID WP_061892358.1
Coordinates 2092473..2092751 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag HUR93_RS10040 Protein ID WP_061892363.1
Coordinates 2092753..2092944 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUR93_RS10000 (2087508) 2087508..2089979 - 2472 WP_061892426.1 exonuclease -
HUR93_RS10005 (2090073) 2090073..2090264 - 192 WP_001083280.1 lysis protein YdfD -
HUR93_RS10010 (2090261) 2090261..2090449 - 189 WP_000854559.1 cell division inhibition protein DicB -
HUR93_RS10015 (2091010) 2091010..2091243 + 234 WP_061892361.1 hypothetical protein -
HUR93_RS10020 (2091221) 2091221..2091628 - 408 WP_061892360.1 hypothetical protein -
HUR93_RS10025 (2091651) 2091651..2091869 - 219 WP_061892359.1 protein YdfC -
HUR93_RS26770 (2091899) 2091899..2092027 - 129 WP_073972170.1 hypothetical protein -
HUR93_RS10030 (2092029) 2092029..2092184 - 156 WP_000379575.1 DUF1391 family protein -
HUR93_RS10035 (2092473) 2092473..2092751 - 279 WP_061892358.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HUR93_RS10040 (2092753) 2092753..2092944 - 192 WP_061892363.1 hypothetical protein Antitoxin
HUR93_RS10045 (2092965) 2092965..2093336 - 372 WP_135405263.1 hypothetical protein -
HUR93_RS10050 (2093433) 2093433..2093735 + 303 WP_000172735.1 transcriptional regulator -
HUR93_RS10055 (2093732) 2093732..2094157 + 426 WP_061892357.1 toxin YdaT family protein -
HUR93_RS10060 (2094229) 2094229..2095296 + 1068 WP_061892356.1 hypothetical protein -
HUR93_RS10065 (2095340) 2095340..2095762 + 423 WP_061892355.1 DUF977 family protein -
HUR93_RS10070 (2095759) 2095759..2095989 + 231 WP_237897963.1 hypothetical protein -
HUR93_RS10075 (2096144) 2096144..2096794 + 651 WP_001138877.1 hypothetical protein -
HUR93_RS10080 (2096781) 2096781..2097902 + 1122 WP_061892725.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2084739..2140925 56186


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10647.22 Da        Isoelectric Point: 5.5647

>T160004 WP_061892358.1 NZ_CP054662:c2092751-2092473 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDVDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T160004 NZ_CP070232:2334127-2335449 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7491.52 Da        Isoelectric Point: 8.6828

>AT160004 WP_061892363.1 NZ_CP054662:c2092944-2092753 [Escherichia coli]
MNRVLSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT160004 NZ_CP070232:2333861-2334127 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References