Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1287185..1288017 | Replicon | chromosome |
| Accession | NZ_CP054662 | ||
| Organism | Escherichia coli strain IGC_RcoliRes_1.1 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A2A2C6E0 |
| Locus tag | HUR93_RS06215 | Protein ID | WP_000854716.1 |
| Coordinates | 1287185..1287559 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A3U2KGT7 |
| Locus tag | HUR93_RS06220 | Protein ID | WP_001285595.1 |
| Coordinates | 1287649..1288017 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HUR93_RS06185 (1282832) | 1282832..1284673 | + | 1842 | WP_000437371.1 | RNA polymerase sigma factor RpoD | - |
| HUR93_RS06190 (1284752) | 1284752..1285258 | - | 507 | WP_000228937.1 | G/U mismatch-specific DNA glycosylase | - |
| HUR93_RS06200 (1285558) | 1285558..1286403 | - | 846 | WP_061892513.1 | DUF4942 domain-containing protein | - |
| HUR93_RS06205 (1286488) | 1286488..1286685 | - | 198 | WP_000839249.1 | DUF957 domain-containing protein | - |
| HUR93_RS06210 (1286697) | 1286697..1287188 | - | 492 | WP_000976843.1 | DUF5983 family protein | - |
| HUR93_RS06215 (1287185) | 1287185..1287559 | - | 375 | WP_000854716.1 | TA system toxin CbtA family protein | Toxin |
| HUR93_RS06220 (1287649) | 1287649..1288017 | - | 369 | WP_001285595.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| HUR93_RS06225 (1288075) | 1288075..1288314 | - | 240 | WP_000692304.1 | DUF987 domain-containing protein | - |
| HUR93_RS06230 (1288377) | 1288377..1288853 | - | 477 | Protein_1218 | RadC family protein | - |
| HUR93_RS06235 (1288869) | 1288869..1289354 | - | 486 | WP_000213718.1 | antirestriction protein | - |
| HUR93_RS06240 (1289446) | 1289446..1290264 | - | 819 | WP_001234704.1 | DUF932 domain-containing protein | - |
| HUR93_RS06245 (1290591) | 1290591..1291790 | - | 1200 | Protein_1221 | autotransporter domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13986.02 Da Isoelectric Point: 7.2426
>T160001 WP_000854716.1 NZ_CP054662:c1287559-1287185 [Escherichia coli]
MKTLPDTHVREASRCPSPVIIWQILLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYLEAK
MKTLPDTHVREASRCPSPVIIWQILLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYLEAK
Download Length: 375 bp
>T160001 NZ_CP070232:c1775343-1774969 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAACATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAACATCGATATCCTCCGGGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13494.33 Da Isoelectric Point: 6.3132
>AT160001 WP_001285595.1 NZ_CP054662:c1288017-1287649 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTSCFGARLVQVGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK
VSDTLPGTTLPDDNHDRPWWGLPCTVTSCFGARLVQVGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT160001 NZ_CP070232:c1775800-1775432 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACTCATCCCGATGACAACAACAGCCACCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTATCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCTCCGGGACAACTCATCCCGATGACAACAACAGCCACCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTATCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2A2C6E0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3U2KGT7 |