Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 49057..49892 Replicon chromosome
Accession NZ_CP054662
Organism Escherichia coli strain IGC_RcoliRes_1.1

Toxin (Protein)


Gene name yeeV Uniprot ID E3PD61
Locus tag HUR93_RS00255 Protein ID WP_001094449.1
Coordinates 49057..49434 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2A3V5X4
Locus tag HUR93_RS00260 Protein ID WP_001280917.1
Coordinates 49524..49892 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUR93_RS00225 (44697) 44697..45620 - 924 WP_000535960.1 carboxylate/amino acid/amine transporter -
HUR93_RS00230 (45731) 45731..46915 - 1185 WP_001172876.1 sugar efflux transporter -
HUR93_RS00235 (47312) 47312..47473 - 162 Protein_46 virulence RhuM family protein -
HUR93_RS00240 (47708) 47708..48553 - 846 WP_061892569.1 DUF4942 domain-containing protein -
HUR93_RS00245 (48638) 48638..48835 - 198 WP_087891818.1 DUF957 domain-containing protein -
HUR93_RS00250 (48911) 48911..49060 - 150 Protein_49 DUF5983 family protein -
HUR93_RS00255 (49057) 49057..49434 - 378 WP_001094449.1 TA system toxin CbtA family protein Toxin
HUR93_RS00260 (49524) 49524..49892 - 369 WP_001280917.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HUR93_RS00265 (49972) 49972..50193 - 222 WP_001546495.1 DUF987 domain-containing protein -
HUR93_RS00270 (50250) 50250..50726 - 477 WP_061892568.1 RadC family protein -
HUR93_RS00275 (50742) 50742..51221 - 480 WP_061892567.1 antirestriction protein -
HUR93_RS00280 (51538) 51538..52356 - 819 WP_061892566.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14162.00 Da        Isoelectric Point: 6.6312

>T159995 WP_001094449.1 NZ_CP054662:c49434-49057 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SSCTHSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ

Download         Length: 378 bp

>T159995 NZ_CP070232:652892-653206 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13794.67 Da        Isoelectric Point: 5.8808

>AT159995 WP_001280917.1 NZ_CP054662:c49892-49524 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLICEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT159995 NZ_CP070232:653203-653619 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3PD61

Antitoxin

Source ID Structure
AlphaFold DB A0A2A3V5X4

References